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    MESR4 Misexpression suppressor of ras 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36986, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MESR4provided by FlyBase
    Official Full Name
    Misexpression suppressor of ras 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0034240
    Locus tag
    Dmel_CG4903
    See related
    AllianceGenome:FB:FBgn0034240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4903; Dmel\CG4903; EP(2)0988; EP0386; EP0988; EP988; mesr4; Mesr4; MSR4
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cellular response to hypoxia; germarium-derived oocyte differentiation; and regulation of gene expression. Located in nucleus. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut primordium; ganglia; germline cell; and mesoderm. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See MESR4 in Genome Data Viewer
    Location:
    54C3-54C5; 2-83 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17547769..17556289)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13435274..13443794)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene cyclophilin-33 Neighboring gene Ribosomal protein L18A Neighboring gene Kinesin-like protein at 54D Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The plant homeodomain finger protein MESR4 is essential for embryonic development in Drosophila. Seong KH, et al. Genesis, 2015 Nov. PMID 26467775
    2. Drosophila MESR4 Gene Ensures Germline Stem Cell Differentiation by Promoting the Transcription of bag of marbles. Szarka-Kovács AB, et al. Cells, 2022 Jun 28. PMID 35805140, Free PMC Article
    3. A Combination of CRISPR/Cas9 and Standardized RNAi as a Versatile Platform for the Characterization of Gene Function. Wissel S, et al. G3 (Bethesda), 2016 Aug 9. PMID 27280787, Free PMC Article
    4. Identification of a novel role for Drosophila MESR4 in lipid metabolism. Tsuda-Sakurai K, et al. Genes Cells, 2015 Apr. PMID 25639854
    5. A misexpression screen identifies genes that can modulate RAS1 pathway signaling in Drosophila melanogaster. Huang AM, et al. Genetics, 2000 Nov. PMID 11063696, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The role of MESR4 in germline cell differentiation
      Title: A Combination of CRISPR/Cas9 and Standardized RNAi as a Versatile Platform for the Characterization of Gene Function.
    2. results suggested that MESR4 is a novel chromatin-binding protein required for proper expression of genes including those regulated by the EGFR signaling pathway during development
      Title: The plant homeodomain finger protein MESR4 is essential for embryonic development in Drosophila.
    3. MESR4 reduces lipid accumulation in the fat body, whereas MESR4 knockdown increases it. MESR4 up-regulates the expression of major lipases, which may account for the reduction in lipid storage in the fat body and the release of free fatty acids.
      Title: Identification of a novel role for Drosophila MESR4 in lipid metabolism.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germarium-derived oocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of PcG protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    misexpression suppressor of ras 4
    Names
    CG4903-PA
    CG4903-PB
    CG4903-PC
    CG4903-PD
    MESR4-PA
    MESR4-PB
    MESR4-PC
    MESR4-PD
    misexpression of Ras 4
    misexpression suppressor of Ras4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17547769..17556289
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103889.2 → NP_001097359.1  misexpression suppressor of ras 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097359.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAV3
      Conserved Domains (3) summary
      sd00017
      Location:1272 → 1288
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1295 → 1315
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd15505
      Location:2110 → 2156
      PHD_ING; PHD finger found in the inhibitor of growth (ING) protein family

    2. NM_001299608.1 → NP_001286537.1  misexpression suppressor of ras 4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286537.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFV9
      Conserved Domains (3) summary
      sd00017
      Location:1270 → 1286
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1293 → 1313
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd15505
      Location:2108 → 2154
      PHD_ING; PHD finger found in the inhibitor of growth (ING) protein family

    3. NM_079051.4 → NP_523775.2  misexpression suppressor of ras 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523775.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAV3
      Related
      FBpp0086102
      Conserved Domains (3) summary
      sd00017
      Location:1272 → 1288
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1295 → 1315
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd15505
      Location:2110 → 2156
      PHD_ING; PHD finger found in the inhibitor of growth (ING) protein family

    4. NM_001299609.1 → NP_001286538.1  misexpression suppressor of ras 4, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286538.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGV3
      Conserved Domains (3) summary
      sd00017
      Location:1252 → 1268
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1275 → 1295
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd15505
      Location:2090 → 2136
      PHD_ING; PHD finger found in the inhibitor of growth (ING) protein family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LFV9 A0A0B4LFV9
    A0A0B4LGV3 A0A0B4LGV3
    A1ZAV3 A1ZAV3
    Q9GU55 Q9GU55

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