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    pyx pyrexia [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38037, updated on 17-Dec-2024

    Summary

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    Official Symbol
    pyxprovided by FlyBase
    Official Full Name
    pyrexiaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035113
    Locus tag
    Dmel_CG17142
    See related
    AllianceGenome:FB:FBgn0035113
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17142; CT33412; Dmel\CG17142; dTRPA2; Pyrexia; pyrx; Pyx; trpA2
    Summary
    Enables monoatomic cation channel activity. Involved in metal ion transport; negative gravitaxis; and response to heat. Part of cation channel complex. Is expressed in spermatozoon. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pyx in Genome Data Viewer
    Location:
    61B2-61B2; 3-1 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (217932..223069, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (217932..223069, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Dis3 like 3'-5' exoribonuclease 2 Neighboring gene pseudo Neighboring gene Kaz1-ORFB Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR42862 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Pyrexia transient receptor potential channel mediates circadian clock synchronization to low temperature cycles in Drosophila melanogaster. Wolfgang W, et al. Proc Biol Sci, 2013 Oct 7. PMID 23926145, Free PMC Article
    2. Artificial selection for odor-guided behavior in Drosophila reveals changes in food consumption. Brown EB, et al. BMC Genomics, 2017 Nov 13. PMID 29132294, Free PMC Article
    3. Temperature integration at the AC thermosensory neurons in Drosophila. Tang X, et al. J Neurosci, 2013 Jan 16. PMID 23325228, Free PMC Article
    4. Positive geotactic behaviors induced by geomagnetic field in Drosophila. Bae JE, et al. Mol Brain, 2016 May 18. PMID 27192976, Free PMC Article
    5. The physiological role of TRP channels in sleep and circadian rhythm. Woodard GE, et al. J Cell Mol Med, 2024 May. PMID 38676362, Free PMC Article

    See all (96) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PERIOD is controlled by the TRPA channel PYREXIA, which protects antennal neurons from faulty signaling that would otherwise interfere with temperature synchronization of the circadian clock neurons in the brain
      Title: Temperature synchronization of the Drosophila circadian clock protein PERIOD is controlled by the TRPA channel PYREXIA.
    2. The Pyrexia (Pyx) TRP channel mediates temperature synchronization in Drosophila melanogaster.
      Title: The Pyrexia transient receptor potential channel mediates circadian clock synchronization to low temperature cycles in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables monoatomic cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in monoatomic cation transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative gravitaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in potassium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cation channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pyrexia
    Names
    CG17142-PA
    CG17142-PB
    pyx-PA
    pyx-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      217932..223069 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138171.2 → NP_612015.1  pyrexia, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612015.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8I0I4, Q9W0T5
      Related
      FBpp0072423
      Conserved Domains (6) summary
      cd00204
      Location:268 → 387
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00520
      Location:556 → 734
      Ion_trans; Ion transport protein
      pfam12796
      Location:270 → 364
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:99 → 153
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:353 → 404
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:268 → 296
      ANK; ANK repeat [structural motif]

    2. NM_167813.2 → NP_728501.1  pyrexia, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728501.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W0T5
      Related
      FBpp0072424
      Conserved Domains (1) summary
      pfam00520
      Location:138 → 316
      Ion_trans; Ion transport protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W0T5.2 Q9W0T5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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