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    Pbgs Porphobilinogen synthase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39402, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pbgsprovided by FlyBase
    Official Full Name
    Porphobilinogen synthaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036271
    Locus tag
    Dmel_CG10335
    See related
    AllianceGenome:FB:FBgn0036271
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10335; delta-ALA-D; Dmdelta-AlaD; Dmel\CG10335; DmPBGS
    Summary
    Enables porphobilinogen synthase activity. Predicted to be involved in heme biosynthetic process. Predicted to be active in cytosol. Is expressed in several structures, including adult head; embryonic anal pad; embryonic dorsal epidermis; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in porphyria cutanea tarda and sickle cell anemia. Orthologous to human ALAD (aminolevulinate dehydratase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Pbgs in Genome Data Viewer
    Location:
    69A4-69A4; 3-38 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12269452..12271345, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12262552..12264445, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene tRNA splicing endonuclease subunit 54 Neighboring gene approximated Neighboring gene long non-coding RNA:CR43991 Neighboring gene uncharacterized protein Neighboring gene Spermine synthase Neighboring gene Inositol polyphosphate 5-phosphatase E

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A structural basis for half-of-the-sites metal binding revealed in Drosophila melanogaster porphobilinogen synthase. Kundrat L, et al. J Biol Chem, 2003 Aug 15. PMID 12794073
    2. The Se(…)S/N interactions as a possible mechanism of δ-aminolevulinic acid dehydratase enzyme inhibition by organoselenium compounds: A computational study. Nogara PA, et al. Comput Toxicol, 2020 Aug. PMID 32572387, Free PMC Article
    3. Diphenyl diselenide [(PhSe)2] inhibits Drosophila melanogaster delta-aminolevulinate dehydratase (delta-ALA-D) gene transcription and enzyme activity. Golombieski RM, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2008 Mar. PMID 17936691
    4. Evaluation of Bis(2-ethylhexyl) phthalate toxicity on the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ) Bg(9). Gaur K, et al. Food Chem Toxicol, 2024 Feb. PMID 38160779
    5. An in vivo genetic screen in Drosophila identifies the orthologue of human cancer/testis gene SPO11 among a network of targets to inhibit lethal(3)malignant brain tumour growth. Rossi F, et al. Open Biol, 2017 Aug. PMID 28855394, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables porphobilinogen synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables porphobilinogen synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables porphobilinogen synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in heme biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tetrapyrrole biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    porphobilinogen synthase
    Names
    CG10335-PA
    CG10335-PB
    Pbgs-PA
    Pbgs-PB
    delta-aminolevulinate dehydratase
    NP_001261752.1
    NP_648564.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      12269452..12271345 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274823.1 → NP_001261752.1  porphobilinogen synthase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261752.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VTV9
      Conserved Domains (1) summary
      cd04824
      Location:6 → 323
      eu_ALAD_PBGS_cysteine_rich; Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the ...

    2. NM_140307.4 → NP_648564.1  porphobilinogen synthase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648564.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VTV9
      Related
      FBpp0075743
      Conserved Domains (1) summary
      cd04824
      Location:6 → 323
      eu_ALAD_PBGS_cysteine_rich; Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VTV9 Q9VTV9

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