Sms Spermine synthase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Smsprovided by FlyBase
Official Full Name: Spermine synthaseprovided by FlyBase
Primary source: FLYBASE:FBgn0036272
Locus tag: Dmel_CG4300
See related: AllianceGenome:FB:FBgn0036272
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0118547.387; CG4300; Dmel\CG4300; dSms; sms
Summary: Enables spermine synthase activity. Involved in spermine biosynthetic process. Is expressed in several structures, including anterior endoderm; dorsal pharyngeal muscle cell; embryonic/larval midgut; embryonic/larval midgut primordium; and mesoderm. Used to study syndromic X-linked intellectual disability Snyder type. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Snyder type. Orthologous to human SMS (spermine synthase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 69A4-69A5; 3-38 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (12271656..12277251, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (12264756..12270351, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reduction of spermine synthase enhances autophagy to suppress Tau accumulation.
Title: Reduction of spermine synthase enhances autophagy to suppress Tau accumulation.
The Role of Spermidine Synthase (SpdS) and Spermine Synthase (Sms) in Regulating Triglyceride Storage in Drosophila.
Title: The Role of Spermidine Synthase (SpdS) and Spermine Synthase (Sms) in Regulating Triglyceride Storage in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables spermine synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables spermine synthase activity	IEA Inferred from Electronic Annotation more info
enables spermine synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in spermine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in spermine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: spermine synthase

Names: CG4300-PA; CG4300-PB; CG4300-PC; CG4300-PD; Sms-PA; Sms-PB; Sms-PC; Sms-PD

NP_001287044.1

EC 2.5.1.22

NP_001287045.1

EC 2.5.1.22

NP_648565.1

EC 2.5.1.22

NP_729798.1

EC 2.5.1.22

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

12271656..12277251 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_140308.3 → NP_648565.1 spermine synthase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_648565.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VTW1

Related

FBpp0075742

Conserved Domains (1) summary

cl17173
Location:136 → 361

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
NM_001300115.1 → NP_001287044.1 spermine synthase, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287044.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JB05

Conserved Domains (1) summary

cl17173
Location:136 → 361

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
NM_168496.2 → NP_729798.1 spermine synthase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729798.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VTW0

Related

FBpp0075741

Conserved Domains (1) summary

cl17173
Location:137 → 362

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
NM_001300116.1 → NP_001287045.1 spermine synthase, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287045.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JGL7

Conserved Domains (1) summary

cl17173
Location:137 → 362

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...