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    Smyd4-2 SET and MYND domain containing, class 4, member 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39414, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Smyd4-2provided by FlyBase
    Official Full Name
    SET and MYND domain containing, class 4, member 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0036282
    Locus tag
    Dmel_CG14122
    See related
    AllianceGenome:FB:FBgn0036282
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14122; Dmel\CG14122; dSmyd4; Smyd4
    Summary
    Enables histone deacetylase binding activity. Involved in compound eye photoreceptor development; eclosion; and negative regulation of gene expression. Located in cytoplasm and nucleus. Is expressed in several structures, including dorsal pharyngeal muscle primordium; larval muscle cell; larval muscle system; mesoderm; and visceral mesoderm derivative. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Smyd4-2 in Genome Data Viewer
    Location:
    69B4-69B4; 3-38 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12399539..12401935, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12392639..12395035, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene sodium chloride cotransporter 69 Neighboring gene long non-coding RNA:CR45824 Neighboring gene uncharacterized protein Neighboring gene Odorant-binding protein 69a Neighboring gene Short Calcium-binding Mitochondrial Carrier Neighboring gene ADP-ribosylation factor GTPase activating protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SMYD proteins: key regulators in skeletal and cardiac muscle development and function. Du SJ, et al. Anat Rec (Hoboken), 2014 Sep. PMID 25125178
    2. Evolutionary History of the Smyd Gene Family in Metazoans: A Framework to Identify the Orthologs of Human Smyd Genes in Drosophila and Other Animal Species. Calpena E, et al. PLoS One, 2015. PMID 26230726, Free PMC Article
    3. A Drosophila Smyd4 homologue is a muscle-specific transcriptional modulator involved in development. Thompson EC, et al. PLoS One, 2008 Aug 20. PMID 18714374, Free PMC Article
    4. RNAi-mediated knockdown showing impaired cell survival in Drosophila wing imaginal disc. Umemori M, et al. Gene Regul Syst Bio, 2009 Feb 19. PMID 19838331, Free PMC Article
    5. The novel regulator of metazoan development SAYP organizes a nuclear coactivator supercomplex. Vorobyeva NE, et al. Cell Cycle, 2009 Jul 15. PMID 19556896

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables histone H3K4 methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in compound eye photoreceptor development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in compound eye photoreceptor development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in eclosion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SET and MYND domain containing, class 4, member 2
    Names
    CG14122-PA
    SET and MYND domain protein 4
    Smyd4
    Smyd4-2-PA
    dSmyd4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      12399539..12401935 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140317.3 → NP_648574.1  SET and MYND domain containing, class 4, member 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648574.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VTX2
      Related
      FBpp0075717
      Conserved Domains (3) summary
      pfam00856
      Location:474 → 513
      SET; SET domain
      pfam01753
      Location:299 → 338
      zf-MYND; MYND finger
      pfam13414
      Location:142 → 205
      TPR_11; TPR repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VTX2 Q9VTX2

    Gene LinkOut

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