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    CG8112 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41033, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8112provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037612
    Locus tag
    Dmel_CG8112
    See related
    AllianceGenome:FB:FBgn0037612
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ACAT; ACAT1; Dmel\CG8112
    Summary
    Predicted to enable O-acyltransferase activity. Predicted to be involved in cholesterol metabolic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including amnioserosa; embryonic/larval hemocyte; procrystal cell; and yolk nucleus. Human ortholog(s) of this gene implicated in Chagas disease; coronary artery disease; and hepatocellular carcinoma. Orthologous to several human genes including SOAT2 (sterol O-acyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8112 in Genome Data Viewer
    Location:
    85A8-85A8; 3-48 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8712933..8715263)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4538655..4540985)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44937 Neighboring gene uncharacterized protein Neighboring gene hunchback Neighboring gene Cyclin-dependent kinase subunit 85A Neighboring gene Transmembrane protein 216 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in the midway gene disrupt a Drosophila acyl coenzyme A: diacylglycerol acyltransferase. Buszczak M, et al. Genetics, 2002 Apr. PMID 11973306, Free PMC Article
    2. Identification of hunchback cis-regulatory DNA conferring temporal expression in neuroblasts and neurons. Hirono K, et al. Gene Expr Patterns, 2012 Jan-Feb. PMID 22033538, Free PMC Article
    3. Cholesterol Dietary Intake and Tumor Cell Homeostasis Drive Early Epithelial Tumorigenesis: A Potential Modelization of Early Prostate Tumorigenesis. Vialat M, et al. Cancers (Basel), 2024 Jun 6. PMID 38893271, Free PMC Article
    4. An Adult Drosophila Glioma Model for Studying Pathometabolic Pathways of Gliomagenesis. Chi KC, et al. Mol Neurobiol, 2019 Jun. PMID 30357574
    5. SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase. Pagac M, et al. Cell Rep, 2016 Nov 1. PMID 27806294, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cholesterol O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cholesterol homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cholesterol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8112-PB
    CG8112-PC
    CG8112-PD
    NP_001246991.1
    NP_001287240.1
    NP_731269.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8712933..8715263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300311.1 → NP_001287240.1  uncharacterized protein Dmel_CG8112, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287240.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGV0

    2. NM_169235.4 → NP_731269.2  uncharacterized protein Dmel_CG8112, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731269.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MYW9, Q9VHN2
      Conserved Domains (1) summary
      cl00738
      Location:231 → 473
      MBOAT; MBOAT, membrane-bound O-acyltransferase family

    3. NM_001260062.2 → NP_001246991.1  uncharacterized protein Dmel_CG8112, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246991.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMP4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LGV0 A0A0B4LGV0
    D3DMP4 D3DMP4
    Q8MYW9 Q8MYW9

    Gene LinkOut

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