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    Burs Bursicon [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42560, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bursprovided by FlyBase
    Official Full Name
    Bursiconprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038901
    Locus tag
    Dmel_CG13419
    See related
    AllianceGenome:FB:FBgn0038901
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Bur alpha; burs; BURS; burs alpha; Burs alpha; burs-alpha; Burs-alpha; BursA; bursalpha; Bursalpha; Bursicon alpha; Bursicon-alpha; CG13419; Dmel\CG13419; frl; tBur
    Summary
    Enables hormone activity and protein heterodimerization activity. Contributes to neuropeptide hormone activity and neuropeptide receptor binding activity. Involved in several processes, including cuticle pigmentation; follicle cell of egg chamber development; and intestinal stem cell homeostasis. Located in extracellular region and terminal bouton. Part of bursicon neuropeptide hormone complex. Is expressed in several structures, including adult brain; adult midgut; ganglia; larval neurosecretory neurons; and larval thoracic segment. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Burs in Genome Data Viewer
    Location:
    93F9-93F9; 3-73 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21769518..21770279)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17595240..17596001)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene metabotropic GABA-B receptor subtype 2 Neighboring gene uncharacterized protein Neighboring gene RNA polymerase I subunit H

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cellular localization of bursicon using antisera against partial peptide sequences of this insect cuticle-sclerotizing neurohormone. Honegger HW, et al. J Comp Neurol, 2002 Oct 14. PMID 12271490
    2. Command and compensation in a neuromodulatory decision network. Luan H, et al. J Neurosci, 2012 Jan 18. PMID 22262886, Free PMC Article
    3. Eclosion gates progression of the adult ecdysis sequence of Drosophila. Peabody NC, et al. J Exp Biol, 2013 Dec 1. PMID 24031052, Free PMC Article
    4. The downregulation of the miniature gene does not replicate miniature loss-of-function phenotypes in Drosophila melanogaster wing to the full extent. Bilousov OO, et al. Tsitol Genet, 2013 Mar-Apr. PMID 23745366
    5. Temporally tuned neuronal differentiation supports the functional remodeling of a neuronal network in Drosophila. Veverytsa L, et al. Proc Natl Acad Sci U S A, 2012 Mar 27. PMID 22393011, Free PMC Article

    See all (116) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bursicon-alpha subunit modulates LGR2 activity in the adult Drosophila melanogaster midgut independently to Bursicon-beta.
      Title: Bursicon-α subunit modulates dLGR2 activity in the adult Drosophila melanogaster midgut independently to Bursicon-β.
    2. acts in cuticle synthesis and degradation by regulating the expression of cuticular protein and chitin metabolizing related genes
      Title: The neuropeptide bursicon acts in cuticle metabolism.
    3. results show that the functions thought to be subserved by CCAP are partially effected by bursicon, and that bursicon plays an important and heretofore undescribed role in ecdysis behavior itself.
      Title: Genetic analysis of ecdysis behavior in Drosophila reveals partially overlapping functions of two unrelated neuropeptides.
    4. Study provides evidence that bursicon release can precede the initiation of larval ecdysis, and that bursicon tans the puparium; results establish bursicon signaling as essential to insect growth and development.
      Title: The essential role of bursicon during Drosophila development.
    5. the results of this study reveal novel neuromodulatory functions for bursicon and support the hypothesis that the BSEG are essential for orchestrating both the behavioral and somatic processes underlying wing expansion.
      Title: Bursicon functions within the Drosophila CNS to modulate wing expansion behavior, hormone secretion, and cell death.
    6. the Bursicon/Rickets signaling pathway is necessary for both wing expansion and initiation of the EMT that leads to removal of the epithelial cells from the wing.
      Title: Bursicon signaling mutations separate the epithelial-mesenchymal transition from programmed cell death during Drosophila melanogaster wing maturation.
    7. identify here Drosophila bioactive bursicon as a heterodimer made of two cystine knot polypeptides
      Title: Drosophila molting neurohormone bursicon is a heterodimer and the natural agonist of the orphan receptor DLGR2.
    8. Bursicon is a heterodimeric cystine knot protein that activates G protein-coupled receptor LGR2.
      Title: Bursicon, the insect cuticle-hardening hormone, is a heterodimeric cystine knot protein that activates G protein-coupled receptor LGR2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hormone activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to neuropeptide hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to neuropeptide hormone activity IC
    Inferred by Curator
    more info
    		 PubMed 
    contributes_to neuropeptide hormone activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to neuropeptide receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables receptor ligand activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in border follicle cell delamination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chitin-based cuticle sclerotization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cuticle pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intestinal stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of bursicon neuropeptide hormone complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of bursicon neuropeptide hormone complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in terminal bouton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bursicon
    Names
    Burs-PA
    CG13419-PA
    bursicon alpha
    bursicon alpha subunit
    bursicon alpha-subunit
    furled wing

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      21769518..21770279
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142726.2 → NP_650983.1  bursicon [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650983.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0APJ5, Q573B6, Q9VD83
      UniProtKB/TrEMBL
      C0MK54
      Related
      FBpp0083529
      Conserved Domains (1) summary
      cl21545
      Location:50 → 138
      GHB_like; Glycoprotein hormone beta chain homologues
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VD83.1 Q9VD83

    Gene LinkOut

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