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    ca claret [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43518, updated on 9-Dec-2024

    Summary

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    Official Symbol
    caprovided by FlyBase
    Official Full Name
    claretprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000247
    Locus tag
    Dmel_CG31037
    See related
    AllianceGenome:FB:FBgn0000247
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bw-p; bw[G]; CG18133; CG18134; CG31037; CG7799; Dmel\CG31037
    Summary
    Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in several processes, including eye pigment granule organization; ommochrome biosynthetic process; and regulation of Rab protein signal transduction. Is expressed in adult head. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    99C2-99C2; 3-99 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29806811..29815047)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25632533..25640769)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Electron transfer flavoprotein beta subunit Neighboring gene uncharacterized protein Neighboring gene non-claret disjunctional Neighboring gene Vacuolar protein sorting 16B Neighboring gene uncharacterized protein Neighboring gene neyo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Development of Eye Colors in Drosophila Melanogaster. Further Studies on the Mutant Claret. Clancy CW. Genetics, 1942 Jul. PMID 17247051, Free PMC Article
    2. [A genetic analysis of mutant chromosomes 3 with a similar spectrum of phenotypic action from geographically distant populations of Drosophila melanogaster]. Vaĭsman NIa, et al. Genetika, 1995 Jul. PMID 7590204
    3. Cytogenetic localization of the acid phosphatase-1 gene in Drosophila melanogaster. Morrison WJ, et al. Genetics, 1978 Mar. PMID 416992, Free PMC Article
    4. The claret locus in Drosophila encodes products required for eyecolor and for meiotic chromosome segregation. Yamamoto AH, et al. EMBO J, 1989 Dec 1. PMID 2479546, Free PMC Article
    5. Ncd motor binding and transport in the spindle. Hallen MA, et al. J Cell Sci, 2008 Nov 15. PMID 18957509, Free PMC Article

    See all (95) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in eye pigment granule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in eye pigment precursor transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in ommochrome biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of Rab protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    claret
    Names
    CG31037-PA
    CG31037-PC
    Rab32 GEF
    ca-PA
    ca-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29806811..29815047
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170430.3 → NP_733309.3  claret, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733309.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NNE1, Q9VAG5
      Related
      FBpp0084850
      Conserved Domains (3) summary
      COG5184
      Location:1158 → 1588
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00415
      Location:1242 → 1291
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam13540
      Location:1558 → 1584
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat

    2. NM_001300664.1 → NP_001287593.1  claret, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287593.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NNE1, Q9VAG5
      Conserved Domains (3) summary
      COG5184
      Location:1158 → 1588
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00415
      Location:1242 → 1291
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam13540
      Location:1558 → 1584
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T9D9 Q8T9D9
    Q9VAG5 Q9VAG5

    Gene LinkOut

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