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    Mpv17 Mitochondrial inner membrane protein MPV17 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43831, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mpv17provided by FlyBase
    Official Full Name
    Mitochondrial inner membrane protein MPV17provided by FlyBase
    Primary source
    FLYBASE:FBgn0039930
    Locus tag
    Dmel_CG11077
    See related
    AllianceGenome:FB:FBgn0039930
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11077; Dmel\CG11077; dMpv17; MPV17; PMP22
    Summary
    Enables monoatomic ion channel activity and uridine transmembrane transporter activity. Involved in monoatomic ion transmembrane transport and uridine transmembrane transport. Is active in mitochondrial inner membrane. Is expressed in adult head; embryonic/larval garland cell; and organism. Used to study Charcot-Marie-Tooth disease type 2EE; mitochondrial DNA depletion syndrome; and mitochondrial DNA depletion syndrome 6. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2EE and mitochondrial DNA depletion syndrome 6. Orthologous to human MPV17 (mitochondrial inner membrane protein MPV17). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See Mpv17 in Genome Data Viewer
    Location:
    102F6-102F6; 4-0 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (1028675..1029361, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (1049301..1049987, complement)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene twin of eyeless Neighboring gene Plexin A Neighboring gene antisense RNA:CR44031 Neighboring gene ATP synthase, beta subunit Neighboring gene uncharacterized protein Neighboring gene Calcium/calmodulin-dependent protein kinase II

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables monoatomic ion channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables uridine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in homeostatic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitochondrial genome maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in monoatomic ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of mitochondrial DNA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in uridine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    mitochondrial inner membrane protein MPV17
    Names
    CG11077-PA
    Mpv17-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      1028675..1029361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143687.4NP_651944.1  mitochondrial inner membrane protein MPV17 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651944.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V492
      Related
      FBpp0088286
      Conserved Domains (1) summary
      pfam04117
      Location:106167
      Mpv17_PMP22; Mpv17 / PMP22 family