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    GstE12 Glutathione S transferase E12 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37960, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GstE12provided by FlyBase
    Official Full Name
    Glutathione S transferase E12provided by FlyBase
    Primary source
    FLYBASE:FBgn0027590
    Locus tag
    Dmel_CG16936
    See related
    AllianceGenome:FB:FBgn0027590
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH04753; CG16936; Dmel\CG16936; gst; GST; gste12; GSTE12
    Summary
    Enables glutathione transferase activity. Involved in glutathione metabolic process. Predicted to be located in cytoplasm. Is expressed in several structures, including adult head; adult heart; embryonic/larval crystal cell; embryonic/larval midgut primordium; and visceral mesoderm derivative. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GstE12 in Genome Data Viewer
    Location:
    60E1-60E1; 2-107 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24766718..24768172, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20654241..20655695, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene spatzle 6 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Epidermal growth factor receptor pathway substrate clone 15 Neighboring gene antisense RNA:CR44067 Neighboring gene eggless

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Euchromatic transposon insertions trigger production of novel Pi- and endo-siRNAs at the target sites in the drosophila germline. Shpiz S, et al. PLoS Genet, 2014 Feb. PMID 24516406, Free PMC Article
    2. S-nitrosoglutathione-induced toxicity in Drosophila melanogaster: Delayed pupation and induced mild oxidative/nitrosative stress in eclosed flies. Lozinsky OV, et al. Comp Biochem Physiol A Mol Integr Physiol, 2013 Jan. PMID 22940110
    3. A Halloween gene noppera-bo encodes a glutathione S-transferase essential for ecdysteroid biosynthesis via regulating the behaviour of cholesterol in Drosophila. Enya S, et al. Sci Rep, 2014 Oct 10. PMID 25300303, Free PMC Article
    4. Epsilon glutathione transferases possess a unique class-conserved subunit interface motif that directly interacts with glutathione in the active site. Wongsantichon J, et al. Biosci Rep, 2015 Oct 20. PMID 26487708, Free PMC Article
    5. Identifying calpain substrates in intact S2 cells of Drosophila. Bozoky Z, et al. Arch Biochem Biophys, 2009 Jan 15. PMID 19038228

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S transferase E12
    Names
    CG16936-PA
    CG16936-PB
    CG16936-PC
    CG16936-PD
    GstE12-PA
    GstE12-PB
    GstE12-PC
    GstE12-PD
    glutathione S-transferase
    glutathione transferase
    NP_001246500.1
    NP_001246501.1
    NP_001286857.1
    NP_611964.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24766718..24768172 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138120.3 → NP_611964.1  glutathione S transferase E12, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611964.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D2NUG2, Q9XYZ9
      Related
      FBpp0072341
      Conserved Domains (3) summary
      cd03177
      Location:92 → 210
      GST_C_Delta_Epsilon; C-terminal, alpha helical domain of Class Delta and Epsilon Glutathione S-transferases
      COG0625
      Location:6 → 201
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03045
      Location:4 → 77
      GST_N_Delta_Epsilon; GST_N family, Class Delta and Epsilon subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including ...

    2. NM_001259571.2 → NP_001246500.1  glutathione S transferase E12, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246500.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D2NUG2, Q9XYZ9
      Conserved Domains (3) summary
      cd03177
      Location:92 → 210
      GST_C_Delta_Epsilon; C-terminal, alpha helical domain of Class Delta and Epsilon Glutathione S-transferases
      COG0625
      Location:6 → 201
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03045
      Location:4 → 77
      GST_N_Delta_Epsilon; GST_N family, Class Delta and Epsilon subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including ...

    3. NM_001259572.2 → NP_001246501.1  glutathione S transferase E12, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246501.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D2NUG2, Q9XYZ9
      Conserved Domains (3) summary
      cd03177
      Location:92 → 210
      GST_C_Delta_Epsilon; C-terminal, alpha helical domain of Class Delta and Epsilon Glutathione S-transferases
      COG0625
      Location:6 → 201
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03045
      Location:4 → 77
      GST_N_Delta_Epsilon; GST_N family, Class Delta and Epsilon subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including ...

    4. NM_001299928.1 → NP_001286857.1  glutathione S transferase E12, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286857.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D2NUG2, Q9XYZ9
      Conserved Domains (3) summary
      cd03177
      Location:92 → 210
      GST_C_Delta_Epsilon; C-terminal, alpha helical domain of Class Delta and Epsilon Glutathione S-transferases
      COG0625
      Location:6 → 201
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03045
      Location:4 → 77
      GST_N_Delta_Epsilon; GST_N family, Class Delta and Epsilon subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XYZ9 Q9XYZ9

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