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    Pld Phospholipase D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35554, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Pldprovided by FlyBase
    Official Full Name
    Phospholipase Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0286511
    Locus tag
    Dmel_CG12110
    See related
    AllianceGenome:FB:FBgn0286511
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12110; Dmel\CG12110; dPld; dPLD; MitoPLD; PC-Pld; phospholipase D; pld; PLD; pld1
    Summary
    Enables phospholipase D activity. Involved in several processes, including gastrulation involving germ band extension; phototransduction; and positive regulation of Golgi vesicle fusion to target membrane. Located in cytoplasmic vesicle. Is expressed in several structures, including adult head; embryonic anal pad; embryonic epipharynx; embryonic hypopharynx; and embryonic large intestine. Human ortholog(s) of this gene implicated in developmental cardiac valvular defect. Orthologous to human PLD1 (phospholipase D1) and PLD2 (phospholipase D2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pld in Genome Data Viewer
    Location:
    42A14-42A14; 2-55 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6242004..6255266)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2129509..2142771)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44161 Neighboring gene tomboy40 Neighboring gene bicoid-interacting protein 3 Neighboring gene long non-coding RNA:CR46075 Neighboring gene long non-coding RNA:CR45127 Neighboring gene jing

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Molecular Target for an Alcohol Chain-Length Cutoff. Chung HW, et al. J Mol Biol, 2019 Jan 18. PMID 30529033, Free PMC Article
    2. Altered hydroxymethylome in the substantia nigra of Parkinson's disease. Min S, et al. Hum Mol Genet, 2022 Oct 10. PMID 35661211, Free PMC Article
    3. Studies on the mechanism of general anesthesia. Pavel MA, et al. Proc Natl Acad Sci U S A, 2020 Jun 16. PMID 32467161, Free PMC Article
    4. Dietary ethanol stimulates the activity of phosphatidylcholine-specific phospholipase D and the formation of phosphatidylethanol in Drosophila melanogaster larvae. Miller RR Jr, et al. Insect Biochem Mol Biol, 1993 Sep. PMID 8353529
    5. Phospholipase D and retromer promote recycling of TRPL ion channel via the endoplasmic reticulum. Wagner K, et al. Traffic, 2022 Jan. PMID 34719094

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phospholipase D activity couples plasma membrane endocytosis with retromer dependent recycling.
      Title: Phospholipase D activity couples plasma membrane endocytosis with retromer dependent recycling.
    2. Propose that MIGA proteins promote mitochondrial fusion by regulating mitochondrial phospholipid metabolism via MitoPLD.
      Title: Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis.
    3. The results suggest that Pld functions to promote trafficking of Golgi-derived fusion-competent vesicles during cellularization.
      Title: A role for Phospholipase D in Drosophila embryonic cellularization.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: 6243270-6243442 mobile_element_type = transposon:INE-1{}1750

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase D activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipase D activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipase D activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellularization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gastrulation involving germ band extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidic acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phototransduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Golgi vesicle fusion to target membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phospholipase D
    Names
    CG12110-PA
    CG12110-PB
    CG12110-PC
    CG12110-PD
    CG12110-PF
    CG12110-PG
    Phosphatidylcholine-specific phospholipase-D
    Pld-PA
    Pld-PB
    Pld-PC
    Pld-PD
    Pld-PF
    Pld-PG
    NP_001137610.1
    NP_523627.3
    NP_724469.2
    NP_724470.2
    NP_724471.2
    NP_724472.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6242004..6255266
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165470.3 → NP_724470.2  phospholipase D, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724470.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KML4, Q9BP35
      Conserved Domains (4) summary
      cd06895
      Location:144 → 345
      PX_PLD; The phosphoinositide binding Phox Homology domain of Phospholipase D
      cd09138
      Location:504 → 648
      PLDc_vPLD1_2_yPLD_like_1; Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins
      cd09141
      Location:946 → 1134
      PLDc_vPLD1_2_yPLD_like_2; Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins
      cd01254
      Location:333 → 478
      PH_PLD; Phospholipase D pleckstrin homology (PH) domain

    2. NM_165469.4 → NP_724469.2  phospholipase D, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724469.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KML4, Q9BP35
      Conserved Domains (4) summary
      cd06895
      Location:144 → 345
      PX_PLD; The phosphoinositide binding Phox Homology domain of Phospholipase D
      cd09138
      Location:504 → 648
      PLDc_vPLD1_2_yPLD_like_1; Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins
      cd09141
      Location:946 → 1134
      PLDc_vPLD1_2_yPLD_like_2; Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins
      cd01254
      Location:333 → 478
      PH_PLD; Phospholipase D pleckstrin homology (PH) domain

    3. NM_165471.3 → NP_724471.2  phospholipase D, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724471.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KML4, Q9BP35
      Conserved Domains (4) summary
      cd06895
      Location:144 → 345
      PX_PLD; The phosphoinositide binding Phox Homology domain of Phospholipase D
      cd09138
      Location:504 → 648
      PLDc_vPLD1_2_yPLD_like_1; Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins
      cd09141
      Location:946 → 1134
      PLDc_vPLD1_2_yPLD_like_2; Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins
      cd01254
      Location:333 → 478
      PH_PLD; Phospholipase D pleckstrin homology (PH) domain

    4. NM_001144138.2 → NP_001137610.1  phospholipase D, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137610.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZT5, Q9BP35
      Conserved Domains (4) summary
      cd06895
      Location:230 → 431
      PX_PLD; The phosphoinositide binding Phox Homology domain of Phospholipase D
      cd09138
      Location:590 → 734
      PLDc_vPLD1_2_yPLD_like_1; Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins
      cd09141
      Location:1032 → 1220
      PLDc_vPLD1_2_yPLD_like_2; Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins
      cd01254
      Location:419 → 564
      PH_PLD; Phospholipase D pleckstrin homology (PH) domain

    5. NM_078903.4 → NP_523627.3  phospholipase D, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523627.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KML4, Q9BP35
      Conserved Domains (4) summary
      cd06895
      Location:144 → 345
      PX_PLD; The phosphoinositide binding Phox Homology domain of Phospholipase D
      cd09138
      Location:504 → 648
      PLDc_vPLD1_2_yPLD_like_1; Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins
      cd09141
      Location:946 → 1134
      PLDc_vPLD1_2_yPLD_like_2; Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins
      cd01254
      Location:333 → 478
      PH_PLD; Phospholipase D pleckstrin homology (PH) domain

    6. NM_165472.3 → NP_724472.3  phospholipase D, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724472.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4UZ54, Q9BP35
      Conserved Domains (5) summary
      cd06895
      Location:144 → 338
      PX_PLD; The phosphoinositide binding Phox Homology domain of Phospholipase D
      cd09138
      Location:486 → 630
      PLDc_vPLD1_2_yPLD_like_1; Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins
      cd09141
      Location:928 → 1116
      PLDc_vPLD1_2_yPLD_like_2; Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins
      PLN02866
      Location:366 → 1245
      PLN02866; phospholipase D
      cd01254
      Location:339 → 460
      PH_PLD; Phospholipase D pleckstrin homology (PH) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4UZ54 A4UZ54
    B7YZT5 B7YZT5
    Q6NR18 Q6NR18
    Q7KML4 Q7KML4
    Q9BP34 Q9BP34
    Q9BP35 Q9BP35

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