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    ScsbetaA Succinyl-coenzyme A synthetase beta subunit, ADP-forming [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41067, updated on 4-Jan-2025

    Summary

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    Official Symbol
    ScsbetaAprovided by FlyBase
    Official Full Name
    Succinyl-coenzyme A synthetase beta subunit, ADP-formingprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037643
    Locus tag
    Dmel_CG11963
    See related
    AllianceGenome:FB:FBgn0037643
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    A-Sbeta; CG11963; CGI 1963; Dmel\CG11963; FBgn0037643; skap; Skap; SkAP
    Summary
    Enables cysteine-type endopeptidase activator activity involved in apoptotic process. Involved in sperm individualization. Located in mitochondrion. Part of Cul3-RING ubiquitin ligase complex. Is expressed in adult head; adult heart; larval neuroblast; spermatid; and spermatozoon. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 5. Orthologous to human SUCLA2 (succinate-CoA ligase ADP-forming subunit beta). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See ScsbetaA in Genome Data Viewer
    Location:
    85B7-85B7; 3-48 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8938724..8943027)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4764405..4768749)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44020 Neighboring gene long non-coding RNA:osk Neighboring gene oskar Neighboring gene uncharacterized protein Neighboring gene ichor Neighboring gene Carbonic anhydrase beta Neighboring gene Ras-related GTP binding A/B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NMFP: a non-negative matrix factorization based preselection method to increase accuracy of identifying mRNA isoforms from RNA-seq data. Ye Y, et al. BMC Genomics, 2016 Jan 11. PMID 26818007, Free PMC Article
    2. Drosophila ortholog of succinyl-CoA synthetase {beta} subunit: a novel modulator of Drosophila KCNQ channels. Gao L, et al. J Neurophysiol, 2008 May. PMID 18385479
    3. BREs mediate both repression and activation of oskar mRNA translation and act in trans. Reveal B, et al. Dev Cell, 2010 Mar 16. PMID 20230756, Free PMC Article
    4. A Krebs Cycle Component Limits Caspase Activation Rate through Mitochondrial Surface Restriction of CRL Activation. Aram L, et al. Dev Cell, 2016 Apr 4. PMID 27052834
    5. A conserved role for the mitochondrial citrate transporter Sea/SLC25A1 in the maintenance of chromosome integrity. Morciano P, et al. Hum Mol Genet, 2009 Nov 1. PMID 19654186

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. modulation of KCNQ channels is mediated by direct interaction of CG11963 with the channel and is not dependent on ATP
      Title: Drosophila ortholog of succinyl-CoA synthetase {beta} subunit: a novel modulator of Drosophila KCNQ channels.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type endopeptidase activator activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables succinate-CoA ligase (ADP-forming) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables succinate-CoA ligase (ADP-forming) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in sperm individualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in succinyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of succinate-CoA ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of succinate-CoA ligase complex (ADP-forming) NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Succinyl-coenzyme A synthetase beta subunit, ADP-forming
    Names
    ATP-specific SCSbeta
    ATP-specific form of the succinyl-CoA synthetase beta subunit
    CG11963-PA
    CG11963-PB
    CG11963-PC
    CG11963-PD
    CG11963-PG
    CG11963-PH
    CG11963-PI
    CG11963-PJ
    ScsbetaA-PA
    ScsbetaA-PB
    ScsbetaA-PC
    ScsbetaA-PD
    ScsbetaA-PG
    ScsbetaA-PH
    ScsbetaA-PI
    ScsbetaA-PJ
    SkpA associated protein
    SkpA-associated protein
    succinyl CoA synthetase
    NP_001097713.1
    NP_001163558.1
    NP_001163559.1
    NP_001189197.2
    NP_001189198.2
    NP_001303475.1
    NP_001303476.1
    NP_649846.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8938724..8943027
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170088.2 → NP_001163559.1  Succinyl-coenzyme A synthetase beta subunit, ADP-forming, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95U38
      Conserved Domains (3) summary
      PLN00124
      Location:28 → 427
      PLN00124; succinyl-CoA ligase [GDP-forming] subunit beta; Provisional
      pfam00549
      Location:307 → 427
      Ligase_CoA; CoA-ligase
      cl17255
      Location:39 → 247
      ATP-grasp_4; ATP-grasp domain

    2. NM_141589.4 → NP_649846.2  Succinyl-coenzyme A synthetase beta subunit, ADP-forming, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHJ8
      Related
      FBpp0081437
      Conserved Domains (3) summary
      PLN00124
      Location:28 → 426
      PLN00124; succinyl-CoA ligase [GDP-forming] subunit beta; Provisional
      pfam00549
      Location:306 → 426
      Ligase_CoA; CoA-ligase
      cl17255
      Location:39 → 247
      ATP-grasp_4; ATP-grasp domain

    3. NM_001316547.1 → NP_001303476.1  Succinyl-coenzyme A synthetase beta subunit, ADP-forming, isoform I [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A126GUR6
      Conserved Domains (3) summary
      PLN00124
      Location:28 → 427
      PLN00124; succinyl-CoA ligase [GDP-forming] subunit beta; Provisional
      pfam00549
      Location:307 → 427
      Ligase_CoA; CoA-ligase
      cl17255
      Location:39 → 247
      ATP-grasp_4; ATP-grasp domain

    4. NM_001202268.3 → NP_001189197.2  Succinyl-coenzyme A synthetase beta subunit, ADP-forming, isoform H [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JCW4
      Conserved Domains (3) summary
      PLN00124
      Location:28 → 426
      PLN00124; succinyl-CoA ligase [GDP-forming] subunit beta; Provisional
      pfam00549
      Location:306 → 426
      Ligase_CoA; CoA-ligase
      cl17255
      Location:39 → 247
      ATP-grasp_4; ATP-grasp domain

    5. NM_001170087.2 → NP_001163558.1  Succinyl-coenzyme A synthetase beta subunit, ADP-forming, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95U38
      Conserved Domains (3) summary
      PLN00124
      Location:28 → 427
      PLN00124; succinyl-CoA ligase [GDP-forming] subunit beta; Provisional
      pfam00549
      Location:307 → 427
      Ligase_CoA; CoA-ligase
      cl17255
      Location:39 → 247
      ATP-grasp_4; ATP-grasp domain

    6. NM_001104243.3 → NP_001097713.1  Succinyl-coenzyme A synthetase beta subunit, ADP-forming, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHJ8
      Conserved Domains (3) summary
      PLN00124
      Location:28 → 426
      PLN00124; succinyl-CoA ligase [GDP-forming] subunit beta; Provisional
      pfam00549
      Location:306 → 426
      Ligase_CoA; CoA-ligase
      cl17255
      Location:39 → 247
      ATP-grasp_4; ATP-grasp domain

    7. NM_001316546.1 → NP_001303475.1  Succinyl-coenzyme A synthetase beta subunit, ADP-forming, isoform J [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A126GUR6
      Conserved Domains (3) summary
      PLN00124
      Location:28 → 427
      PLN00124; succinyl-CoA ligase [GDP-forming] subunit beta; Provisional
      pfam00549
      Location:307 → 427
      Ligase_CoA; CoA-ligase
      cl17255
      Location:39 → 247
      ATP-grasp_4; ATP-grasp domain

    8. NM_001202269.2 → NP_001189198.2  Succinyl-coenzyme A synthetase beta subunit, ADP-forming, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JCW4
      Conserved Domains (3) summary
      PLN00124
      Location:28 → 426
      PLN00124; succinyl-CoA ligase [GDP-forming] subunit beta; Provisional
      pfam00549
      Location:306 → 426
      Ligase_CoA; CoA-ligase
      cl17255
      Location:39 → 247
      ATP-grasp_4; ATP-grasp domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4JCW4 A0A0B4JCW4
    A0A126GUR6 A0A126GUR6
    Q95U38 Q95U38
    Q9VHJ8 Q9VHJ8

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