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    TfIIEalpha Transcription factor IIEalpha [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39313, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TfIIEalphaprovided by FlyBase
    Official Full Name
    Transcription factor IIEalphaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015828
    Locus tag
    Dmel_CG10415
    See related
    AllianceGenome:FB:FBgn0015828
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10415; Dmel\CG10415; dTFIIE-L; dTFIIEL; TfIIE; TFIIE; TFIIE-L; TfIIEa; TFIIEalpha
    Summary
    Involved in mRNA transcription by RNA polymerase II. Located in nucleus. Part of transcription factor TFIIE complex. Is expressed in organism. Orthologous to human GTF2E1 (general transcription factor IIE subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See TfIIEalpha in Genome Data Viewer
    Location:
    68D2-68D2; 3-36 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11682038..11683805)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11675138..11676905)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45882 Neighboring gene long non-coding RNA:CR45884 Neighboring gene antisense RNA:CR45885 Neighboring gene Sugar baby Neighboring gene Pallidin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila TFIIE: purification, cloning, and functional reconstitution. Wang X, et al. Proc Natl Acad Sci U S A, 1997 Jan 21. PMID 9012800, Free PMC Article
    2. Control of transcription by Krüppel through interactions with TFIIB and TFIIE beta. Sauer F, et al. Nature, 1995 May 11. PMID 7753175
    3. Purification of the Drosophila RNA polymerase II general transcription factors. Austin RJ, et al. Proc Natl Acad Sci U S A, 1996 Jun 11. PMID 8650170, Free PMC Article
    4. Fractionation of the general RNA polymerase II transcription factors from Drosophila embryos. Wampler SL, et al. J Biol Chem, 1990 Dec 5. PMID 2250021
    5. DNA template and activator-coactivator requirements for transcriptional synergism by Drosophila bicoid. Sauer F, et al. Science, 1995 Dec 15. PMID 8525377

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mRNA transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription factor TFIIE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIE complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of transcription factor TFIIE complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription factor IIEalpha
    Names
    CG10415-PA
    TfIIEalpha-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11682038..11683805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079302.4 → NP_524026.1  transcription factor IIEalpha [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524026.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96880
      Related
      FBpp0075839
      Conserved Domains (3) summary
      smart00531
      Location:43 → 188
      TFIIE; Transcription initiation factor IIE
      pfam11521
      Location:357 → 429
      TFIIE-A_C; C-terminal general transcription factor TFIIE alpha
      cl21459
      Location:30 → 137
      HTH; Helix-turn-helix domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O96880 O96880

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