U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Uba1 Ubiquitin activating enzyme 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35998, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Uba1provided by FlyBase
    Official Full Name
    Ubiquitin activating enzyme 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0023143
    Locus tag
    Dmel_CG1782
    See related
    AllianceGenome:FB:FBgn0023143
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    2/31; CG1782; Dmel\CG1782; DmUba1; E1; FBtr0088499; l(2)03405; l(2)05642; l(2)s3484; Uba; Uba 1; uba-1; UBA-1; uba1; UBA1
    Summary
    Enables ubiquitin activating enzyme activity. Involved in several processes, including larval midgut cell programmed cell death; mitophagy; and nervous system development. Located in dendrite. Is expressed in several structures, including CNS glial cell; ganglia; gut section; head epidermis primordium; and mesoderm. Human ortholog(s) of this gene implicated in VEXAS syndrome and X-linked spinal muscular atrophy 2. Orthologous to several human genes including UBA1 (ubiquitin like modifier activating enzyme 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Uba1 in Genome Data Viewer
    Location:
    46A1-46A1; 2-61 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9688289..9693328, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5575794..5580833, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Matrix metalloproteinase 2 Neighboring gene long non-coding RNA:CR44070 Neighboring gene transfer RNA:initiator Methionine-CAT 2-1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Curbing the excesses of youth: molecular insights into axonal pruning. Kantor DB, et al. Neuron, 2003 Jun 19. PMID 12818170
    2. Mutation in E1, the ubiquitin activating enzyme, reduces Drosophila lifespan and results in motor impairment. Liu HY, et al. PLoS One, 2013. PMID 23382794, Free PMC Article
    3. Drosophila matrix metalloproteinases are required for tissue remodeling, but not embryonic development. Page-McCaw A, et al. Dev Cell, 2003 Jan. PMID 12530966
    4. Establishment of a novel axon pruning model of Drosophila motor neuron. Xu W, et al. Biol Open, 2023 Jan 1. PMID 36606515, Free PMC Article
    5. Synergistic effects on dopamine cell death in a Drosophila model of chronic toxin exposure. Martin CA, et al. Neurotoxicology, 2014 Sep. PMID 25160001, Free PMC Article

    See all (124) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Uba1, the E1 enzyme used in ubiquitylation, is required for autophagy and reduction of cell size.
      Title: Uba1 functions in Atg7- and Atg3-independent autophagy.
    2. These mutants of the E1, the ubiquitin activating enzyme exhibited further reduced lifespan and severe motor impairment.
      Title: Mutation in E1, the ubiquitin activating enzyme, reduces Drosophila lifespan and results in motor impairment.
    3. knockdown of SUMO or its E1 and E2 enzymes robustly disrupts proliferating cells in the developing eye, without any detectable effects on the development or differentiation of neighboring post-mitotic cells
      Title: A differential requirement for SUMOylation in proliferating and non-proliferating cells during Drosophila development.
    4. Data demonstrate that maintaining sufficient E1 function is required both cell autonomously and non-cell autonomously to prevent inappropriate Ras-ERK-dependent growth and proliferation in vivo.
      Title: Impairment of ubiquitylation by mutation in Drosophila E1 promotes both cell-autonomous and non-cell-autonomous Ras-ERK activation in vivo.
    5. This study showed that a reduction in uba1 activity can promote tissue growth in a multicellular organism and raise the possibility that changes in uba1 activity may occur during normal development or in cancer.
      Title: Mutation of the gene encoding the ubiquitin activating enzyme ubal causes tissue overgrowth in Drosophila.
    6. phenotypic analysis of Uba1 demonstrates that impaired ubiquitin conjugation has significant consequences for the organism
      Title: The E1 ubiquitin-activating enzyme Uba1 in Drosophila controls apoptosis autonomously and tissue growth non-autonomously.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin activating enzyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-like modifier activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in follicle cell of egg chamber development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval midgut cell programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid storage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mushroom body development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein polyubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    ubiquitin activating enzyme 1
    Names
    CG1782-PA
    CG1782-PC
    E1
    E1 ligase
    Uba1-PA
    Uba1-PC
    ubiquitin activating enzyme
    ubiquitin-activating enzyme (E1)
    NP_001260831.1
    NP_477310.2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9688289..9693328 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057962.5 → NP_477310.2  ubiquitin activating enzyme 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477310.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O46111, Q8T0L3, Q9V5A7
      Related
      FBpp0087583
      Conserved Domains (4) summary
      cd01490
      Location:606 → 1144
      Ube1_repeat2; Ubiquitin activating enzyme (E1), repeat 2. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
      cd01491
      Location:199 → 574
      Ube1_repeat1; Ubiquitin activating enzyme (E1), repeat 1. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
      TIGR01408
      Location:194 → 1188
      Ube1; ubiquitin-activating enzyme E1
      pfam16191
      Location:447 → 510
      E1_4HB; Ubiquitin-activating enzyme E1 four-helix bundle

    2. NM_001273902.1 → NP_001260831.1  ubiquitin activating enzyme 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260831.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KF46, O46111
      Conserved Domains (4) summary
      cd01490
      Location:423 → 961
      Ube1_repeat2; Ubiquitin activating enzyme (E1), repeat 2. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
      cd01491
      Location:16 → 391
      Ube1_repeat1; Ubiquitin activating enzyme (E1), repeat 1. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
      TIGR01408
      Location:11 → 1005
      Ube1; ubiquitin-activating enzyme E1
      pfam16191
      Location:264 → 327
      E1_4HB; Ubiquitin-activating enzyme E1 four-helix bundle
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KF46 A0A0B4KF46
    O46111 O46111
    Q8T0L3 Q8T0L3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous