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    Snoo Sno oncogene [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 5740414, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Snooprovided by FlyBase
    Official Full Name
    Sno oncogeneprovided by FlyBase
    Primary source
    FLYBASE:FBgn0085450
    Locus tag
    Dmel_CG34421
    See related
    AllianceGenome:FB:FBgn0085450
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG34421; CG7093; CG7233; Dmel\CG34421; dSki; DskiL; dsno; dSno; dsnoN; dSnoN; l(2)SH1402; l(2)SH2 1402; Sno; SnoA; SnoI; snoN; SnoN; SnoN2; snoo
    Old locus tag
    CG7093; CG7233; Dmel_CG7093; Dmel_CG7233
    Summary
    Enables co-SMAD binding activity. Involved in dendrite morphogenesis; regulation of SMAD protein signal transduction; and regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Located in cytosol and nucleus. Is expressed in several structures, including Bolwig organ; egg chamber; ganglia; and germarium. Orthologous to human SKIL (SKI like proto-oncogene) and SKI (SKI proto-oncogene). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Snoo in Genome Data Viewer
    Location:
    28D2-28D3; 2-29 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7891187..7984196, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7891187..7984196, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Serpin 28Da Neighboring gene Serpin 28Db Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44996 Neighboring gene peste Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SnoN residue (1-366) attenuates hypertrophic scars through resistance to transforming growth factor-β1-induced degradation. Sun GF, et al. Lab Invest, 2019 Dec. PMID 31409891
    2. Snoo and Dpp Act as Spatial and Temporal Regulators Respectively of Adult Progenitor Cells in the Drosophila Trachea. Djabrayan NJ, et al. PLoS Genet, 2016 Mar. PMID 26942411, Free PMC Article
    3. fussel (fuss)--A negative regulator of BMP signaling in Drosophila melanogaster. Fischer S, et al. PLoS One, 2012. PMID 22879948, Free PMC Article
    4. Drosophila SnoN modulates growth and patterning by antagonizing TGF-beta signalling. Ramel MC, et al. Mech Dev, 2007 Apr. PMID 17289352
    5. The role of Dpp and its inhibitors during eggshell patterning in Drosophila. Shravage BV, et al. Development, 2007 Jun. PMID 17507396

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. downregulated in hypertrophic scar fibroblasts owing to TGF-beta1/Smad-induced degradation
      Title: SnoN residue (1-366) attenuates hypertrophic scars through resistance to transforming growth factor-β1-induced degradation.
    2. we elucidate the genetic network elicited by Snoo and Dpp activity. These results illustrate a regulatory mechanism that translates intrinsic potential and extrinsic cues into the facultative stem cell features of differentiated progenitors.
      Title: Snoo and Dpp Act as Spatial and Temporal Regulators Respectively of Adult Progenitor Cells in the Drosophila Trachea.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SMAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SMAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables co-SMAD binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of BMP signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of activin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of SMAD protein signal transduction IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Sno oncogene
    Names
    CG34421-PB
    CG34421-PC
    CG34421-PD
    CG34421-PG
    Sno-oncogene
    Snoo-PB
    Snoo-PC
    Snoo-PD
    Snoo-PG
    lethal (2) SH1402
    snoN

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7891187..7984196 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103646.4 → NP_001097116.1  Sno oncogene, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097116.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0PDV1, Q00G30
      Conserved Domains (2) summary
      smart01046
      Location:226 → 317
      c-SKI_SMAD_bind; c-SKI Smad4 binding domain
      pfam02437
      Location:114 → 207
      Ski_Sno; SKI/SNO/DAC family

    2. NM_001103647.3 → NP_001097117.1  Sno oncogene, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097117.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0PDV1, Q00G30
      Conserved Domains (2) summary
      smart01046
      Location:226 → 317
      c-SKI_SMAD_bind; c-SKI Smad4 binding domain
      pfam02437
      Location:114 → 207
      Ski_Sno; SKI/SNO/DAC family

    3. NM_135320.3 → NP_609164.3  Sno oncogene, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609164.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0PDV1, Q00G30
      Conserved Domains (2) summary
      smart01046
      Location:226 → 317
      c-SKI_SMAD_bind; c-SKI Smad4 binding domain
      pfam02437
      Location:114 → 207
      Ski_Sno; SKI/SNO/DAC family

    4. NM_001103645.4 → NP_001097115.1  Sno oncogene, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097115.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0PDV1, Q00G30
      Conserved Domains (2) summary
      smart01046
      Location:226 → 317
      c-SKI_SMAD_bind; c-SKI Smad4 binding domain
      pfam02437
      Location:114 → 207
      Ski_Sno; SKI/SNO/DAC family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0PDV0 A0PDV0
    A0PDV1 A0PDV1
    A0PDV2 A0PDV2
    Q00G30 Q00G30
    Q00G33 Q00G33
    Q00G34 Q00G34
    Q06KR8 Q06KR8
    Q2XY50 Q2XY50
    Q961E6 Q961E6

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