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    Atg3 Autophagy-related 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40044, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Atg3provided by FlyBase
    Official Full Name
    Autophagy-related 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0036813
    Locus tag
    Dmel_CG6877
    See related
    AllianceGenome:FB:FBgn0036813
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    atg3; ATG3; Aut-1; Aut1; AUT1; CG6877; dAtg3; Dmel\CG6877; Draut1
    Summary
    Predicted to enable Atg8-family conjugating enzyme activity. Involved in T-tubule organization; cellular response to starvation; and macroautophagy. Located in autophagosome and cytosol. Is expressed in several structures, including adult head; central brain primordium; embryonic/larval garland cell; embryonic/larval midgut primordium; and ganglia. Orthologous to human ATG3 (autophagy related 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Atg3 in Genome Data Viewer
    Location:
    75D8-75D8; 3-45 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18748687..18750483)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18741787..18743583)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Mediator complex subunit 11 Neighboring gene nufip Neighboring gene long non-coding RNA:CR45938 Neighboring gene ftz transcription factor 1 Neighboring gene long non-coding RNA:CR45939

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila homolog of Aut1 is essential for autophagy and development. Juhász G, et al. FEBS Lett, 2003 May 22. PMID 12753924
    2. EndophilinA-dependent coupling between activity-induced calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation. Bademosi AT, et al. Neuron, 2023 May 3. PMID 36827984, Free PMC Article
    3. Endophilin-B regulates autophagy during synapse development and neurodegeneration. Hernandez-Diaz S, et al. Neurobiol Dis, 2022 Feb. PMID 34933093
    4. Chemical Genetic Screen in Drosophila Germline Uncovers Small Molecule Drugs That Sensitize Stem Cells to Insult-Induced Apoptosis. Ishibashi JR, et al. Cells, 2021 Oct 16. PMID 34685753, Free PMC Article
    5. The autophagy-related gene Atg101 in Drosophila regulates both neuron and midgut homeostasis. Guo T, et al. J Biol Chem, 2019 Apr 5. PMID 30760524, Free PMC Article

    See all (92) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Draut1 is essential for autophagy and development.
      Title: The Drosophila homolog of Aut1 is essential for autophagy and development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables Atg8-family conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Atg8-family conjugating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Atg8-family conjugating enzyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in T-tubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in larval midgut cell programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in autophagosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Autophagy-related 3
    Names
    Atg3-PA
    Aut1
    Autophagy-specific gene 3
    CG6877-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      18748687..18750483
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140802.3 → NP_649059.1  Autophagy-related 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649059.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVS6
      Related
      FBpp0074822
      Conserved Domains (3) summary
      pfam03986
      Location:8 → 135
      Autophagy_N; Autophagocytosis associated protein (Atg3), N-terminal domain
      pfam03987
      Location:219 → 280
      Autophagy_act_C; Autophagocytosis associated protein, active-site domain
      pfam10381
      Location:301 → 325
      Autophagy_C; Autophagocytosis associated protein C-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVS6 Q9VVS6

    Gene LinkOut

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