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    c(2)M crossover suppressor on 2 of Manheim [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34964, updated on 9-Dec-2024

    Summary

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    Official Symbol
    c(2)Mprovided by FlyBase
    Official Full Name
    crossover suppressor on 2 of Manheimprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028525
    Locus tag
    Dmel_CG4249
    See related
    AllianceGenome:FB:FBgn0028525
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS02740.10; c(2)m; C(2)M; CG4249; Dmel\CG4249; DS02740.10; mei-910; MEI-910
    Summary
    Involved in resolution of meiotic recombination intermediates. Located in synaptonemal complex. Is expressed in oocyte; organism; and presumptive oocyte. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See c(2)M in Genome Data Viewer
    Location:
    35F1-35F1; 2-52 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16303264..16305940)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16303264..16305940)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 303a1 Neighboring gene heixuedian Neighboring gene uncharacterized protein Neighboring gene Glia maturation factor Neighboring gene uncharacterized protein Neighboring gene Syntaxin 5 Neighboring gene cornichon

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Juxtaposition of C(2)M and the transverse filament protein C(3)G within the central region of Drosophila synaptonemal complex. Anderson LK, et al. Proc Natl Acad Sci U S A, 2005 Mar 22. PMID 15767569, Free PMC Article
    2. The Synaptonemal complex component C(2)M regulates meiotic crossing over in Drosophila. Manheim EA, et al. Curr Biol, 2003 Feb 18. PMID 12593793
    3. Drosophila BubR1 is essential for meiotic sister-chromatid cohesion and maintenance of synaptonemal complex. Malmanche N, et al. Curr Biol, 2007 Sep 4. PMID 17702574, Free PMC Article
    4. The formation of the central element of the synaptonemal complex may occur by multiple mechanisms: the roles of the N- and C-terminal domains of the Drosophila C(3)G protein in mediating synapsis and recombination. Jeffress JK, et al. Genetics, 2007 Dec. PMID 17947423, Free PMC Article
    5. Synaptonemal complex-dependent centromeric clustering and the initiation of synapsis in Drosophila oocytes. Takeo S, et al. Curr Biol, 2011 Nov 8. PMID 22036182

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. C(2)M appears to function within the synaptonemal complex during prophase I.
      Title: The Drosophila meiotic kleisin C(2)M functions before the meiotic divisions.
    2. model of synaptonemal complex structure in which C(2)M links C(3)G to the lateral elements
      Title: Juxtaposition of C(2)M and the transverse filament protein C(3)G within the central region of Drosophila synaptonemal complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in resolution of meiotic recombination intermediates IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in synaptonemal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    crossover suppressor on 2 of manheim
    Names
    CG4249-PA
    alpha-kleisin
    c(2)M-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16303264..16305940
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135944.3 → NP_609788.1  crossover suppressor on 2 of manheim [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609788.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95SD1, Q9VJL5
      Related
      FBpp0080388
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJL5 Q9VJL5

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