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    CCT5 Chaperonin containing TCP1 subunit 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36308, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CCT5provided by FlyBase
    Official Full Name
    Chaperonin containing TCP1 subunit 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0010621
    Locus tag
    Dmel_CG8439
    See related
    AllianceGenome:FB:FBgn0010621
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA.GM12270; BcDNA:GM12270; cct5; Cct5; CG8439; Dmel\CG8439; l(2)06444; TCP-1epsilon; Tcp1-epsilon; TCP1-epsilon
    Summary
    Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Predicted to be part of chaperonin-containing T-complex. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; germline cell; and gut section. Used to study intrinsic cardiomyopathy and sensory peripheral neuropathy. Orthologous to human CCT5 (chaperonin containing TCP1 subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CCT5 in Genome Data Viewer
    Location:
    48E4-48E4; 2-66 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12174802..12177516)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8062307..8065021)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ornithine decarboxylase antizyme Neighboring gene antisense RNA:CR46194 Neighboring gene mir-281-2 stem loop Neighboring gene mir-281-1 stem loop Neighboring gene antisense RNA:CR45264 Neighboring gene Endonuclease G Neighboring gene uncharacterized protein Neighboring gene washout

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Polycomb Requires Chaperonin Containing TCP-1 Subunit 7 for Maintaining Gene Silencing in Drosophila. Shaheen N, et al. Front Cell Dev Biol, 2021. PMID 34660585, Free PMC Article
    2. TRiC/CCT chaperonins are essential for maintaining myofibril organization, cardiac physiological rhythm, and lifespan. Melkani GC, et al. FEBS Lett, 2017 Nov. PMID 28963798, Free PMC Article
    3. CCT complex restricts neuropathogenic protein aggregation via autophagy. Pavel M, et al. Nat Commun, 2016 Dec 8. PMID 27929117, Free PMC Article
    4. Structures of the Gβ-CCT and PhLP1-Gβ-CCT complexes reveal a mechanism for G-protein β-subunit folding and Gβγ dimer assembly. Plimpton RL, et al. Proc Natl Acad Sci U S A, 2015 Feb 24. PMID 25675501, Free PMC Article
    5. Chaperonin TRiC/CCT supports mitotic exit and entry into endocycle in Drosophila. Ohhara Y, et al. PLoS Genet, 2019 Apr. PMID 31034473, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of chaperonin-containing T-complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    chaperonin containing TCP1 subunit 5
    Names
    CCT5-PA
    CCT5-PB
    CG8439-PA
    CG8439-PB
    T-complex chaperonin 5

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12174802..12177516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078983.4 → NP_523707.1  chaperonin containing TCP1 subunit 5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523707.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VV32, Q7KKI0
      Related
      FBpp0087095
      Conserved Domains (2) summary
      cd03339
      Location:11 → 536
      TCP1_epsilon; TCP-1 (CTT or eukaryotic type II) chaperonin family, epsilon subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
      pfam00118
      Location:45 → 534
      Cpn60_TCP1; TCP-1/cpn60 chaperonin family

    2. NM_165867.2 → NP_725107.1  chaperonin containing TCP1 subunit 5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725107.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z8U4, C8VV32
      Related
      FBpp0087096
      Conserved Domains (2) summary
      cd03339
      Location:5 → 506
      TCP1_epsilon; TCP-1 (CTT or eukaryotic type II) chaperonin family, epsilon subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
      pfam00118
      Location:15 → 504
      Cpn60_TCP1; TCP-1/cpn60 chaperonin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z8U4 A1Z8U4
    Q7KKI0 Q7KKI0

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