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    Suv3 Suv3 helicase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40543, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Suv3provided by FlyBase
    Official Full Name
    Suv3 helicaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037232
    Locus tag
    Dmel_CG9791
    See related
    AllianceGenome:FB:FBgn0037232
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9791; Dmel\CG9791; dmsuv3; SUV3
    Summary
    Predicted to enable DNA binding activity; DNA helicase activity; and RNA helicase activity. Involved in mitochondrial RNA processing and regulation of gene expression. Located in mitochondrion. Is expressed in adult head. Orthologous to human SUPV3L1 (Suv3 like RNA helicase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Suv3 in Genome Data Viewer
    Location:
    82A3-82A3; 3-47.1 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4311555..4315398)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (137277..140094)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR46140 Neighboring gene Vacuolar protein sorting 24 Neighboring gene Melanization Protease 1 Neighboring gene Synaptotagmin 14 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SUV3 helicase is required for correct processing of mitochondrial transcripts. Clemente P, et al. Nucleic Acids Res, 2015 Sep 3. PMID 26152302, Free PMC Article
    2. Defects of mitochondrial RNA turnover lead to the accumulation of double-stranded RNA in vivo. Pajak A, et al. PLoS Genet, 2019 Jul. PMID 31365523, Free PMC Article
    3. Mitochondrial DNA maintenance in Drosophila melanogaster. Rodrigues APC, et al. Biosci Rep, 2022 Nov 30. PMID 36254835, Free PMC Article
    4. Interspecies analysis of MYC targets identifies tRNA synthetases as mediators of growth and survival in MYC-overexpressing cells. Zirin J, et al. Proc Natl Acad Sci U S A, 2019 Jul 16. PMID 31262815, Free PMC Article
    5. Genome-wide identification and characterization of tissue-specific RNA editing events in D. melanogaster and their potential role in regulating alternative splicing. Mazloomian A, et al. RNA Biol, 2015. PMID 26512413, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on acid anhydrides IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial RNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial RNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial mRNA polyadenylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial tRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitochondrial translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitochondrial mRNA stability IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of mitochondrial degradosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Suv3 helicase
    Names
    CG9791-PC
    CG9791-PD
    SUV3 helicase
    Suv3-PC
    Suv3-PD
    NP_001303458.1
    NP_649452.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      4311555..4315398
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316529.1 → NP_001303458.1  Suv3 helicase, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H1UUI2, Q95TU1, Q9VN03
      Conserved Domains (4) summary
      COG0513
      Location:195 → 507
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd00046
      Location:193 → 323
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:357 → 461
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam12513
      Location:614 → 657
      SUV3_C; Mitochondrial degradasome RNA helicase subunit C terminal

    2. NM_141195.4 → NP_649452.3  Suv3 helicase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649452.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H1UUI2, Q95TU1, Q9VN03
      Conserved Domains (4) summary
      COG0513
      Location:195 → 507
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd00046
      Location:193 → 323
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:357 → 461
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam12513
      Location:614 → 657
      SUV3_C; Mitochondrial degradasome RNA helicase subunit C terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VN03.3 Q9VN03

    Gene LinkOut

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