abs abstrakt [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: absprovided by FlyBase
Official Full Name: abstraktprovided by FlyBase
Primary source: FLYBASE:FBgn0015331
Locus tag: Dmel_CG14637
See related: AllianceGenome:FB:FBgn0015331
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: ABS; anon-WO0118547.315; CG14637; DDX41; Dmel\CG14637; DmRH23; l(3)00620; l(3)04505; l(3)06862; l(3)06863
Summary: Predicted to enable RNA helicase activity and mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in gonad and organism. Human ortholog(s) of this gene implicated in myeloproliferative neoplasm. Orthologous to human DDX41 (DEAD-box helicase 41). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 82A1-82A1; 3-47.1 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (4233047..4235041)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (58769..60763)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0583 (e-PCR)
- UniSTS:27091

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	IC Inferred by Curator more info	PubMed
involved_in mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	HDA more info	PubMed
part_of precatalytic spliceosome	HDA more info	PubMed
part_of spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: abstrakt

Names: CG14637-PA; abs-PA; abstract

NP_524220.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

4233047..4235041

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079496.4 → NP_524220.1 abstrakt [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524220.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9U6D0, Q9V3C0

Related

FBpp0078606

Conserved Domains (3) summary

smart00487
Location:192 → 397

DEXDc; DEAD-like helicases superfamily

cd00268
Location:179 → 393

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

pfam00271
Location:414 → 523

Helicase_C; Helicase conserved C-terminal domain