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    Prosalpha5 Proteasome alpha5 subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36951, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prosalpha5provided by FlyBase
    Official Full Name
    Proteasome alpha5 subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0016697
    Locus tag
    Dmel_CG10938
    See related
    AllianceGenome:FB:FBgn0016697
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    154644_at; alpha-5; Alpha-5; alpha5; alpha5_dm; CG10938; Dmel\CG10938; PRCZ; prosalpha5; prosMA5; ProsMA5; PSA5_DROME; PSMA5
    Summary
    Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Acts upstream of with a positive effect on determination of adult lifespan. Part of proteasome core complex. Is expressed in several structures, including adult head; adult heart; anterior endoderm anlage; germline cell; and mesoderm. Used to study neurodegenerative disease. Orthologous to human PSMA5 (proteasome 20S subunit alpha 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Prosalpha5 in Genome Data Viewer
    Location:
    54B7-54B7; 2-82 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17412767..17413769)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13300272..13301274)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Cathelicidin-like antimicrobial protein Neighboring gene Vajk4 Neighboring gene connector enhancer of ksr Neighboring gene lethal (2) k01209 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Toxicity of C9orf72-associated dipeptide repeat peptides is modified by commonly used protein tags. Morón-Oset J, et al. Life Sci Alliance, 2023 Sep. PMID 37308278, Free PMC Article
    2. Proteomic mapping of Drosophila transgenic elav.L-GAL4/+ brain as a tool to illuminate neuropathology mechanisms. Velentzas AD, et al. Sci Rep, 2020 Mar 25. PMID 32214222, Free PMC Article
    3. Differential toxicity of ataxin-3 isoforms in Drosophila models of Spinocerebellar Ataxia Type 3. Johnson SL, et al. Neurobiol Dis, 2019 Dec. PMID 31310802, Free PMC Article
    4. The Drosophila TGF-beta/Activin-like ligands Dawdle and Myoglianin appear to modulate adult lifespan through regulation of 26S proteasome function in adult muscle. Langerak S, et al. Biol Open, 2018 Apr 26. PMID 29615416, Free PMC Article
    5. Molecular cloning of the Drosophila melanogaster gene alpha5_dm encoding a 20S proteasome alpha-type subunit. Zaiss D, et al. Gene, 1997 Nov 12. PMID 9409776

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    acts_upstream_of_positive_effect determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome core complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    proteasome alpha5 subunit
    Names
    20s proteasome
    CG10938-PA
    CG10938-PB
    Prosalpha5-PA
    Prosalpha5-PB
    alpha-subunit of 20S proteasome
    alpha5
    proteasome alpha subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17412767..17413769
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166221.4 → NP_725669.1  proteasome alpha5 subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725669.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E942, Q95083, Q9V809
      Related
      FBpp0086066
      Conserved Domains (2) summary
      PRK03996
      Location:8 → 243
      PRK03996; proteasome subunit alpha; Provisional
      cd03753
      Location:8 → 222
      proteasome_alpha_type_5; proteasome_alpha_type_5. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...

    2. NM_057854.4 → NP_477202.2  proteasome alpha5 subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477202.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E942, Q95083, Q9V809
      Related
      FBpp0086067
      Conserved Domains (2) summary
      PRK03996
      Location:8 → 243
      PRK03996; proteasome subunit alpha; Provisional
      cd03753
      Location:8 → 222
      proteasome_alpha_type_5; proteasome_alpha_type_5. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95083.2 Q95083

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