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    NO66 Nucleolar protein 66 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31374, updated on 17-Dec-2024

    Summary

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    Official Symbol
    NO66provided by FlyBase
    Official Full Name
    Nucleolar protein 66provided by FlyBase
    Primary source
    FLYBASE:FBgn0266570
    Locus tag
    Dmel_CG2982
    See related
    AllianceGenome:FB:FBgn0266570
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-4Bd; CG2982; Dmel\CG2982
    Summary
    Predicted to enable histone H3K36 demethylase activity; histone H3K4me/H3K4me2/H3K4me3 demethylase activity; and iron ion binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Located in nucleolus. Is expressed in adult head and organism. Used to study alcohol use disorder. Orthologous to human RIOX1 (ribosomal oxygenase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See NO66 in Genome Data Viewer
    Location:
    4B6-4B6; 1-7 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4319438..4321745)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (4213471..4215778)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44957 Neighboring gene long non-coding RNA:CR46156 Neighboring gene meiotic 9 Neighboring gene mitochondrial ribosomal protein L33 Neighboring gene no receptor potential A Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. JmjC: cupin metalloenzyme-like domains in jumonji, hairless and phospholipase A2beta. Clissold PM, et al. Trends Biochem Sci, 2001 Jan. PMID 11165500
    2. The Drosophila meiotic recombination gene mei-9 encodes a homologue of the yeast excision repair protein Rad1. Sekelsky JJ, et al. Genetics, 1995 Oct. PMID 8647398, Free PMC Article
    3. Epigenetic Mechanisms of Alcohol Neuroadaptation: Insights from Drosophila. Ramirez-Roman ME, et al. J Exp Neurosci, 2018. PMID 29899666, Free PMC Article
    4. Dynamic redox balance directs the oocyte-to-embryo transition via developmentally controlled reactive cysteine changes. Petrova B, et al. Proc Natl Acad Sci U S A, 2018 Aug 21. PMID 30082411, Free PMC Article
    5. JmjC domain proteins modulate circadian behaviors and sleep in Drosophila. Shalaby NA, et al. Sci Rep, 2018 Jan 16. PMID 29339751, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 2-oxoglutarate-dependent dioxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone H3K36 demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K36 demethylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone H3K4 demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K4me/H3K4me2/H3K4me3 demethylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables iron ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nucleolar protein 66
    Names
    CG2982-PB
    CG2982-PC
    NO66-PB
    NO66-PC
    anon-4Bd
    NP_572160.1
    NP_726923.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      4319438..4321745
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_131932.4 → NP_572160.1  nucleolar protein 66, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572160.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K4H4
      UniProtKB/TrEMBL
      E2QD64
      Related
      FBpp0070616
      Conserved Domains (1) summary
      cl21464
      Location:229 → 534
      cupin_like; Conserved domain found in cupin and related proteins

    2. NM_167007.3 → NP_726923.1  nucleolar protein 66, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726923.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K4H4
      UniProtKB/TrEMBL
      E2QD64
      Related
      FBpp0309175
      Conserved Domains (1) summary
      cl21464
      Location:229 → 534
      cupin_like; Conserved domain found in cupin and related proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E2QD64 E2QD64
    Q7K4H4.1 Q7K4H4

    Gene LinkOut

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