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    rudhira rudhira [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32136, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rudhiraprovided by FlyBase
    Official Full Name
    rudhiraprovided by FlyBase
    Primary source
    FLYBASE:FBgn0266019
    Locus tag
    Dmel_CG43154
    See related
    AllianceGenome:FB:FBgn0266019
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Liang-2.41; CG1905; CG32662; CG32663; CG43154; clone 2.41; Dmel\CG43154; Drudh; DRudh; Rudh
    Old locus tag
    Dmel_CG32662; Dmel_CG32663
    Summary
    Involved in macropinocytosis. Located in cytoplasm. Is expressed in adult brain; adult head; adult pericardial cell; embryonic/larval garland cell; and larval pericardial cell. Used to study Hengel-Maroofian-Schols syndrome. Human ortholog(s) of this gene implicated in Hengel-Maroofian-Schols syndrome. Orthologous to human BCAS3 (BCAS3 microtubule associated cell migration factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rudhira in Genome Data Viewer
    Location:
    10E6-10F1; 1-36 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11816898..11837460)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11710931..11731493)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Heat shock protein 70 cognate 3 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43908 Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 28c1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bi-allelic loss-of-function variants in BCAS3 cause a syndromic neurodevelopmental disorder. Hengel H, et al. Am J Hum Genet, 2021 Jun 3. PMID 34022130, Free PMC Article
    2. Macromolecular uptake in Drosophila pericardial cells requires rudhira function. Das D, et al. Exp Cell Res, 2008 May 1. PMID 18355807
    3. Gene expression analysis in post-embryonic pericardial cells of Drosophila. Das D, et al. Gene Expr Patterns, 2008 Feb. PMID 18060846
    4. Two-step mechanism for selective incorporation of lncRNA into a chromatin modifier. Müller M, et al. Nucleic Acids Res, 2020 Jul 27. PMID 32510132, Free PMC Article
    5. Wispy, the Drosophila homolog of GLD-2, is required during oogenesis and egg activation. Cui J, et al. Genetics, 2008 Apr. PMID 18430932, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in macropinocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    rudhira
    Names
    CG43154-PB
    CG43154-PC
    CG43154-PD
    CG43154-PE
    CG43154-PF
    CG43154-PG
    rudhira-PB
    rudhira-PC
    rudhira-PD
    rudhira-PE
    rudhira-PF
    rudhira-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11816898..11837460
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258702.1 → NP_001245631.1  rudhira, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245631.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SY41
      UniProtKB/TrEMBL
      M9NED8
      Conserved Domains (1) summary
      pfam12490
      Location:635 → 822
      BCAS3; Breast carcinoma amplified sequence 3

    2. NM_167309.3 → NP_727567.1  rudhira, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727567.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SY41
      UniProtKB/TrEMBL
      M9NED8
      Conserved Domains (1) summary
      pfam12490
      Location:635 → 822
      BCAS3; Breast carcinoma amplified sequence 3

    3. NM_001382106.1 → NP_001368979.1  rudhira, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6H2EFK5
      Conserved Domains (1) summary
      pfam12490
      Location:648 → 818
      BCAS3; Breast carcinoma amplified sequence 3

    4. NM_001258703.2 → NP_001245632.1  rudhira, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245632.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYU0
      Conserved Domains (1) summary
      pfam12490
      Location:635 → 822
      BCAS3; Breast carcinoma amplified sequence 3

    5. NM_132522.3 → NP_572750.3  rudhira, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572750.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYU0
      Conserved Domains (1) summary
      pfam12490
      Location:635 → 822
      BCAS3; Breast carcinoma amplified sequence 3

    6. NM_001272534.1 → NP_001259463.1  rudhira, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259463.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SY41
      UniProtKB/TrEMBL
      M9NED8
      Conserved Domains (1) summary
      pfam12490
      Location:635 → 822
      BCAS3; Breast carcinoma amplified sequence 3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A6H2EFK5 A0A6H2EFK5
    M9NED8 M9NED8
    Q8SY41.1 Q8SY41
    Q960P3 Q960P3
    Q9VYU0 Q9VYU0

    Gene LinkOut

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