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    GCS2alpha Glucosidase 2 alpha subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 49953, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GCS2alphaprovided by FlyBase
    Official Full Name
    Glucosidase 2 alpha subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027588
    Locus tag
    Dmel_CG14476
    See related
    AllianceGenome:FB:FBgn0027588
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH04962; CG14476; clot#312; Dmel\CG14476
    Summary
    Predicted to enable glucan 1,3-alpha-glucosidase activity. Predicted to be involved in N-glycan processing. Located in endomembrane system and extracellular region. Is expressed in several structures, including adult head; adult heart; anterior endoderm; gut section; and mesoderm. Human ortholog(s) of this gene implicated in polycystic kidney disease; polycystic kidney disease 3; and polycystic liver disease. Orthologous to several human genes including GANAB (glucosidase II alpha subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GCS2alpha in Genome Data Viewer
    Location:
    20A4-20A4; 1-66 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (21600502..21605264, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (21471529..21476291, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46472 Neighboring gene long non-coding RNA:CR44711 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two isoforms of trimming glucosidase II exist in mammalian tissues and cell lines but not in yeast and insect cells. Ziak M, et al. Biochem Biophys Res Commun, 2001 Jan 12. PMID 11162524
    2. Characterization of the flamenco region of the Drosophila melanogaster genome. Robert V, et al. Genetics, 2001 Jun. PMID 11404334, Free PMC Article
    3. [Analysis of the structure and expression of the cluster of Drosophila melanogaster genes DIP1, CG32500, CG32819, and CG14476 in the flamenco gene region]. Potapova MV, et al. Genetika, 2009 Oct. PMID 19947543
    4. Discovery of insect and human dengue virus host factors. Sessions OM, et al. Nature, 2009 Apr 23. PMID 19396146, Free PMC Article
    5. Mutations in four glycosyl hydrolases reveal a highly coordinated pathway for rhodopsin biosynthesis and N-glycan trimming in Drosophila melanogaster. Rosenbaum EE, et al. PLoS Genet, 2014 May. PMID 24785692, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Analysis of the structure and expression of the cluster of Drosophila melanogaster genes DIP1, CG32500, CG32819, and CG14476 in the flamenco gene region
      Title: [Analysis of the structure and expression of the cluster of Drosophila melanogaster genes DIP1, CG32500, CG32819, and CG14476 in the flamenco gene region].
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c21604380-21604032 mobile_element_type = transposon:INE-1{}2000

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alpha-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucan 1,3-alpha-glucosidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    located_in extracellular region HDA PubMed 
    part_of glucosidase II complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glucosidase 2 alpha subunit
    Names
    CG14476-PA
    CG14476-PB
    CG14476-PC
    CG14476-PD
    CG14476-PE
    GCS2alpha-PA
    GCS2alpha-PB
    GCS2alpha-PC
    GCS2alpha-PD
    GCS2alpha-PE
    alpha-glucosidase
    glucosidase II
    NP_652145.1
    NP_728434.1
    NP_728435.1
    NP_728436.1
    NP_728437.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      21600502..21605264 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167758.2 → NP_728435.1  glucosidase 2 alpha subunit, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728435.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KMM4
      Related
      FBpp0070058
      Conserved Domains (3) summary
      cd06603
      Location:362 → 833
      GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
      cd14752
      Location:224 → 362
      GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
      pfam01055
      Location:343 → 792
      Glyco_hydro_31; Glycosyl hydrolases family 31

    2. NM_143888.5 → NP_652145.1  glucosidase 2 alpha subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652145.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KMM4
      Related
      FBpp0070057
      Conserved Domains (3) summary
      cd06603
      Location:362 → 833
      GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
      cd14752
      Location:224 → 362
      GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
      pfam01055
      Location:343 → 792
      Glyco_hydro_31; Glycosyl hydrolases family 31

    3. NM_167757.3 → NP_728434.1  glucosidase 2 alpha subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728434.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KMM4
      Related
      FBpp0070059
      Conserved Domains (3) summary
      cd06603
      Location:362 → 833
      GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
      cd14752
      Location:224 → 362
      GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
      pfam01055
      Location:343 → 792
      Glyco_hydro_31; Glycosyl hydrolases family 31

    4. NM_167760.1 → NP_728437.1  glucosidase 2 alpha subunit, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728437.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KMM4
      Related
      FBpp0070060, FBtr0070061
      Conserved Domains (3) summary
      cd06603
      Location:362 → 833
      GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
      cd14752
      Location:224 → 362
      GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
      pfam01055
      Location:343 → 792
      Glyco_hydro_31; Glycosyl hydrolases family 31

    5. NM_167759.2 → NP_728436.1  glucosidase 2 alpha subunit, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728436.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KMM4
      Related
      FBpp0070061
      Conserved Domains (3) summary
      cd06603
      Location:362 → 833
      GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
      cd14752
      Location:224 → 362
      GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
      pfam01055
      Location:343 → 792
      Glyco_hydro_31; Glycosyl hydrolases family 31
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KMM4 Q7KMM4

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