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    Unc-115a Uncoordinated 115a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 261629, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Unc-115aprovided by FlyBase
    Official Full Name
    Uncoordinated 115aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051352
    Locus tag
    Dmel_CG31352
    See related
    AllianceGenome:FB:FBgn0051352
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.21; CG31352; CG9489; Dmel\CG31352; dunc-115; Dunc-115; unc-115; unc-15a
    Summary
    Predicted to enable actin filament binding activity. Involved in photoreceptor cell axon guidance. Located in nucleoplasm. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; gut section; mesoderm; and synaptic neuropil domain. Orthologous to human ABLIM1 (actin binding LIM protein 1); ABLIM2 (actin binding LIM protein family member 2); and ABLIM3 (actin binding LIM protein family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Unc-115a in Genome Data Viewer
    Location:
    85E4-85E5; 3-49 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9694386..9705417, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5520108..5531139, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Uncoordinated 115b Neighboring gene p24-related-2 Neighboring gene uncharacterized protein Neighboring gene trabid Neighboring gene small Cajal body-specific RNA : PsiU1-6 Neighboring gene dalmatian

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional Analysis of Actin-Binding Proteins in the Central Nervous System of Drosophila. He Q, et al. Methods Mol Biol, 2022. PMID 34542862
    2. Drosophila Dunc-115 mediates axon projection through actin binding. Roblodowski C, et al. Invert Neurosci, 2017 Mar. PMID 28124181
    3. Role of Drosophila gene dunc-115 in nervous system. Garcia MC, et al. Invert Neurosci, 2007 Jun. PMID 17505850
    4. Precise maps of RNA polymerase reveal how promoters direct initiation and pausing. Kwak H, et al. Science, 2013 Feb 22. PMID 23430654, Free PMC Article
    5. Generation of Inducible Gene-Switched GAL4 Expressed in the Drosophila Female Germline Stem Cell Niche. Ke YT, et al. G3 (Bethesda), 2019 Jun 5. PMID 31018943, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lamellipodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in photoreceptor cell axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm HDA PubMed 

    General protein information

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    Preferred Names
    uncoordinated 115a
    Names
    CG31352-PA
    CG31352-PB
    CG31352-PC
    CG31352-PE
    CG31352-PF
    CG31352-PG
    CG31352-PH
    CG31352-PJ
    Unc-115a-PA
    Unc-115a-PB
    Unc-115a-PC
    Unc-115a-PE
    Unc-115a-PF
    Unc-115a-PG
    Unc-115a-PH
    Unc-115a-PJ

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9694386..9705417 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300328.1 → NP_001287257.1  uncoordinated 115a, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287257.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGZ0, E8NH19
      Conserved Domains (6) summary
      cd09327
      Location:8 → 59
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:64 → 119
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:173 → 224
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:232 → 288
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:753 → 787
      VHP; Villin headpiece domain
      pfam16182
      Location:726 → 751
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    2. NM_001300329.1 → NP_001287258.1  uncoordinated 115a, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287258.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LI11, E8NH01
      Conserved Domains (6) summary
      cd09327
      Location:46 → 97
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:102 → 157
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:211 → 262
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:270 → 326
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:791 → 825
      VHP; Villin headpiece domain
      pfam16182
      Location:764 → 789
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    3. NM_001170102.2 → NP_001163573.1  uncoordinated 115a, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163573.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIH3, E8NH01
      Conserved Domains (6) summary
      cd09327
      Location:46 → 97
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:102 → 157
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:211 → 262
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:270 → 326
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:810 → 844
      VHP; Villin headpiece domain
      pfam16182
      Location:783 → 808
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    4. NM_001300330.1 → NP_001287259.1  uncoordinated 115a, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287259.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGY1, C4IY10
      Conserved Domains (6) summary
      cd09327
      Location:30 → 81
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:86 → 141
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:195 → 246
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:254 → 310
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:794 → 828
      VHP; Villin headpiece domain
      pfam16182
      Location:767 → 792
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    5. NM_001300331.1 → NP_001287260.1  uncoordinated 115a, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287260.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGY0, C4IY10
      Conserved Domains (6) summary
      cd09327
      Location:8 → 59
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:64 → 119
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:173 → 224
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:232 → 288
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:738 → 772
      VHP; Villin headpiece domain
      pfam16182
      Location:711 → 736
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    6. NM_001170104.3 → NP_001163575.2  uncoordinated 115a, isoform J [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4IY10, E1JIH1
      Conserved Domains (6) summary
      cd09327
      Location:8 → 59
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:64 → 119
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:173 → 224
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:232 → 288
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:779 → 813
      VHP; Villin headpiece domain
      pfam16182
      Location:752 → 777
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    7. NM_141673.6 → NP_649930.4  uncoordinated 115a, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649930.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4IY10, Q95V20, Q9VH91
      Related
      FBpp0081570
      Conserved Domains (6) summary
      cd09327
      Location:8 → 59
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:64 → 119
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:173 → 224
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:232 → 288
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:772 → 806
      VHP; Villin headpiece domain
      pfam16182
      Location:745 → 770
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    8. NM_001170103.2 → NP_001163574.1  uncoordinated 115a, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163574.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIH2, E8NH19
      Conserved Domains (6) summary
      cd09327
      Location:41 → 92
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:97 → 152
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:206 → 257
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:265 → 321
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:805 → 839
      VHP; Villin headpiece domain
      pfam16182
      Location:778 → 803
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LGY0 A0A0B4LGY0
    A0A0B4LGY1 A0A0B4LGY1
    A0A0B4LGZ0 A0A0B4LGZ0
    A0A0B4LI11 A0A0B4LI11
    E1JIH1 E1JIH1
    E1JIH2 E1JIH2
    E1JIH3 E1JIH3
    Q9VH91 Q9VH91

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