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    TORIP Torsin interacting protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40158, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TORIPprovided by FlyBase
    Official Full Name
    Torsin interacting proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036908
    Locus tag
    Dmel_CG14103
    See related
    AllianceGenome:FB:FBgn0036908
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14103; dLap1; dLAP1; Dmel\CG14103; LAP1; Torip
    Summary
    Predicted to enable ATPase regulator activity. Predicted to be involved in membrane organization. Part of nuclear membrane protein complex. Is active in nuclear envelope. Is expressed in adult head and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See TORIP in Genome Data Viewer
    Location:
    76C6-76C6; 3-46 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19803738..19805080, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19796838..19798180, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Sterol regulatory element binding protein Neighboring gene mir-33 stem loop Neighboring gene uncharacterized protein Neighboring gene Ionotropic receptor 76a Neighboring gene uncharacterized protein Neighboring gene Coiled-coil domain-containing 58 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Torsins Are Essential Regulators of Cellular Lipid Metabolism. Grillet M, et al. Dev Cell, 2016 Aug 8. PMID 27453503
    2. The BED finger, a novel DNA-binding domain in chromatin-boundary-element-binding proteins and transposases. Aravind L. Trends Biochem Sci, 2000 Sep. PMID 10973053
    3. Drosophila importin alpha1 performs paralog-specific functions essential for gametogenesis. Ratan R, et al. Genetics, 2008 Feb. PMID 18245351, Free PMC Article
    4. Torsin and NEP1R1-CTDNEP1 phosphatase affect interphase nuclear pore complex insertion by lipid-dependent and lipid-independent mechanisms. Jacquemyn J, et al. EMBO J, 2021 Sep 1. PMID 34313336, Free PMC Article
    5. Molecular genetic analysis of Chd3 and polytene chromosome region 76B-D in Drosophila melanogaster. Cooper MT, et al. Genetics, 2010 Jul. PMID 20439780, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase regulator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear membrane protein complex IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    torsin interacting protein
    Names
    CG14103-PA
    CG14103-PB
    TORIP-PA
    TORIP-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19803738..19805080 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275136.1 → NP_001262065.1  torsin interacting protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262065.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RG3, Q9VW40

    2. NM_140892.4 → NP_649149.1  torsin interacting protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649149.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RG3, Q9VW40
      Related
      FBpp0074696
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VW40 Q9VW40

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