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    Wdr33 WD repeat domain 33 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40698, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wdr33provided by FlyBase
    Official Full Name
    WD repeat domain 33provided by FlyBase
    Primary source
    FLYBASE:FBgn0046222
    Locus tag
    Dmel_CG1109
    See related
    AllianceGenome:FB:FBgn0046222
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD24014; CG1109; Dmel\CG1109; WDR33
    Summary
    Predicted to be involved in mRNA 3'-end processing. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; ganglia; and mesoderm. Used to study primary ovarian insufficiency. Orthologous to human WDR33 (WD repeat domain 33). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Wdr33 in Genome Data Viewer
    Location:
    83B8-83B8; 3-47.5 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5660635..5665169)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1486357..1490891)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Mediator complex subunit 27 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44093 Neighboring gene antisense RNA:CR46134 Neighboring gene Xe7 Neighboring gene Autophagy-related 17 Neighboring gene Rab23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Use of circular RNAs as markers of readthrough transcription to identify factors regulating cleavage/polyadenylation events. Liang D, et al. Methods, 2021 Dec. PMID 33882363, Free PMC Article
    2. Causal and Candidate Gene Variants in a Large Cohort of Women With Primary Ovarian Insufficiency. Gorsi B, et al. J Clin Endocrinol Metab, 2022 Feb 17. PMID 34718612, Free PMC Article
    3. RNAi screening in Drosophila cells identifies new modifiers of mutant huntingtin aggregation. Doumanis J, et al. PLoS One, 2009 Sep 30. PMID 19789644, Free PMC Article
    4. 3'-End processing of histone pre-mRNAs in Drosophila: U7 snRNP is associated with FLASH and polyadenylation factors. Sabath I, et al. RNA, 2013 Dec. PMID 24145821, Free PMC Article
    5. The TORC1-Regulated CPA Complex Rewires an RNA Processing Network to Drive Autophagy and Metabolic Reprogramming. Tang HW, et al. Cell Metab, 2018 May 1. PMID 29606597, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mRNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat domain 33
    Names
    CG1109-PA
    CG1109-PB
    Wdr33-PA
    Wdr33-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5660635..5665169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169091.2 → NP_730982.1  WD repeat domain 33, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730982.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961C0, Q9VNG2
      Related
      FBpp0078362
      Conserved Domains (3) summary
      COG2319
      Location:148 → 432
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:146 → 429
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:149 → 186
      7WD40; WD40 repeat [structural motif]

    2. NM_169092.2 → NP_730983.1  WD repeat domain 33, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730983.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961C0, Q9VNG2
      Related
      FBpp0078363
      Conserved Domains (3) summary
      COG2319
      Location:148 → 432
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:146 → 429
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:149 → 186
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VNG2 Q9VNG2

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