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    Ih I[[h]] channel [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36589, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ihprovided by FlyBase
    Official Full Name
    I[[h]] channelprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263397
    Locus tag
    Dmel_CG8585
    See related
    AllianceGenome:FB:FBgn0263397
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH25778; CG8585; CR30068; Dmel\CG8585; DmIh; DMIH; I[[h]]
    Old locus tag
    Dmel_CR30068
    Summary
    Predicted to enable voltage-gated potassium channel activity. Involved in several processes, including determination of adult lifespan; locomotor rhythm; and regulation of amine transport. Predicted to be located in membrane. Predicted to be part of HCN channel complex. Is expressed in several structures, including adult aorta; adult head; embryonic cardioblast; lamina monopolar neurons; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome; brain disease (multiple); and heart conduction disease (multiple). Orthologous to several human genes including HCN2 (hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2); HCN3 (hyperpolarization activated cyclic nucleotide gated potassium channel 3); and HCN4 (hyperpolarization activated cyclic nucleotide gated potassium channel 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    50E6-50F1; 2-69 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14276130..14300095)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10163635..10187600)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Selenophosphate synthetase 1 Neighboring gene convoluted Neighboring gene tejas Neighboring gene Shroom

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of a putative voltage- and cyclic nucleotide-gated ion channel present in the antennae and eyes of Drosophila melanogaster. Marx T, et al. Invert Neurosci, 1999-2000. PMID 12491074
    2. Variants of the Drosophila melanogaster Ih-channel are generated by different splicing. Gisselmann G, et al. Insect Biochem Mol Biol, 2005 May. PMID 15804582
    3. Functional study of hyperpolarization activated channel (Ih) in Drosophila behavior. Chen Z, et al. Sci China Life Sci, 2012 Jan. PMID 22314484
    4. The Ih Channel Gene Promotes Synaptic Transmission and Coordinated Movement in Drosophila melanogaster. Hegle AP, et al. Front Mol Neurosci, 2017. PMID 28286469, Free PMC Article
    5. Ih current is necessary to maintain normal dopamine fluctuations and sleep consolidation in Drosophila. Gonzalo-Gomez A, et al. PLoS One, 2012. PMID 22574167, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to light intensity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in circadian sleep/wake cycle, sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in optomotor response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of circadian sleep/wake cycle, sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proboscis extension reflex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of dopamine secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of glutamate secretion, neurotransmission IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of membrane depolarization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of membrane potential in photoreceptor cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of HCN channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    I[[h]] channel
    Names
    CG8585-PB
    CG8585-PC
    CG8585-PE
    CG8585-PF
    CG8585-PG
    CG8585-PH
    CG8585-PI
    CG8585-PJ
    CG8585-PK
    CG8585-PL
    CG8585-PM
    Ih channel
    Ih-PB
    Ih-PC
    Ih-PE
    Ih-PF
    Ih-PG
    Ih-PH
    Ih-PI
    Ih-PJ
    Ih-PK
    Ih-PL
    Ih-PM
    Ih-channel
    drosophila melanogaster I[[h]]-channel
    putative Ih-channel
    putative-voltage-and-cyclic-nucleotide-gated-ion-channel

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14276130..14300095
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001038858.4 → NP_001033947.1  I[[h]] channel, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033947.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z9N8, Q56JI0
      Conserved Domains (4) summary
      COG0664
      Location:1081 → 1204
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:1087 → 1196
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00520
      Location:771 → 1017
      Ion_trans; Ion transport protein
      pfam08412
      Location:709 → 751
      Ion_trans_N; Ion transport protein N-terminal

    2. NM_001038859.4 → NP_001033948.1  I[[h]] channel, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033948.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z9N7, Q56JH7
      Conserved Domains (4) summary
      COG0664
      Location:1118 → 1241
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:1124 → 1233
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00520
      Location:771 → 1054
      Ion_trans; Ion transport protein
      pfam08412
      Location:709 → 751
      Ion_trans_N; Ion transport protein N-terminal

    3. NM_001144195.3 → NP_001137667.1  I[[h]] channel, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137667.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZE7, Q56JI0
      Conserved Domains (4) summary
      COG0664
      Location:1086 → 1209
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:1092 → 1201
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00520
      Location:771 → 1022
      Ion_trans; Ion transport protein
      pfam08412
      Location:709 → 751
      Ion_trans_N; Ion transport protein N-terminal

    4. NM_001144196.3 → NP_001137668.1  I[[h]] channel, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137668.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZE8, Q56JH7
      Conserved Domains (4) summary
      COG0664
      Location:1113 → 1236
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:1119 → 1228
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00520
      Location:771 → 1049
      Ion_trans; Ion transport protein
      pfam08412
      Location:709 → 751
      Ion_trans_N; Ion transport protein N-terminal

    5. NM_001038856.4 → NP_001033945.1  I[[h]] channel, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033945.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F7VJU3, Q56JH9
      Conserved Domains (2) summary
      PLN03192
      Location:69 → 505
      PLN03192; Voltage-dependent potassium channel; Provisional
      pfam08412
      Location:37 → 79
      Ion_trans_N; Ion transport protein N-terminal

    6. NM_001144197.3 → NP_001137669.1  I[[h]] channel, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137669.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZE9
      Conserved Domains (1) summary
      pfam08412
      Location:709 → 751
      Ion_trans_N; Ion transport protein N-terminal

    7. NM_001259390.2 → NP_001246319.1  I[[h]] channel, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246319.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F7VJU3, Q56JH9
      Conserved Domains (2) summary
      PLN03192
      Location:69 → 505
      PLN03192; Voltage-dependent potassium channel; Provisional
      pfam08412
      Location:37 → 79
      Ion_trans_N; Ion transport protein N-terminal

    8. NM_001259388.2 → NP_001246317.1  I[[h]] channel, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246317.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95T40
      Conserved Domains (1) summary
      pfam08412
      Location:37 → 79
      Ion_trans_N; Ion transport protein N-terminal

    9. NM_001259389.1 → NP_001246318.1  I[[h]] channel, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246318.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F7VJU3, Q56JH9
      Conserved Domains (2) summary
      PLN03192
      Location:69 → 505
      PLN03192; Voltage-dependent potassium channel; Provisional
      pfam08412
      Location:37 → 79
      Ion_trans_N; Ion transport protein N-terminal

    10. NM_001259391.2 → NP_001246320.1  I[[h]] channel, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246320.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F7VJU3, Q56JH9
      Conserved Domains (2) summary
      PLN03192
      Location:69 → 505
      PLN03192; Voltage-dependent potassium channel; Provisional
      pfam08412
      Location:37 → 79
      Ion_trans_N; Ion transport protein N-terminal

    11. NM_001038857.3 → NP_001033946.2  I[[h]] channel, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033946.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z9P0, F7VJU3
      Conserved Domains (2) summary
      PLN03192
      Location:52 → 488
      PLN03192; Voltage-dependent potassium channel; Provisional
      pfam08412
      Location:20 → 62
      Ion_trans_N; Ion transport protein N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z9N7 A1Z9N7
    A1Z9N8 A1Z9N8
    A1Z9P0 A1Z9P0
    B7YZE7 B7YZE7
    B7YZE8 B7YZE8
    B7YZE9 B7YZE9
    Q3YNC2 Q3YNC2
    Q3YNC3 Q3YNC3
    Q56JH7 Q56JH7
    Q56JH8 Q56JH8
    Q56JH9 Q56JH9
    Q56JI0 Q56JI0
    Q8IGX2 Q8IGX2
    Q95T40 Q95T40
    Q9Y1J9 Q9Y1J9

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