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    dpp decapentaplegic [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33432, updated on 17-Dec-2024

    Summary

    Official Symbol
    dppprovided by FlyBase
    Official Full Name
    decapentaplegicprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000490
    Locus tag
    Dmel_CG9885
    See related
    AllianceGenome:FB:FBgn0000490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    blk; Bmp; BMP; CG9885; Dm-DPP; DmDPP; Dmel\CG9885; Dpp; DPP; DPP-C; Dpp/TGFbeta; Hin-d; ho; l(2)10638; l(2)22Fa; l(2)k17036; M(2)23AB; M(2)LS1; shv; Tg; TGF-b; TGF-beta; Tgfbeta; TGFbeta
    Summary
    Enables several functions, including heparin binding activity; protein dimerization activity; and signaling receptor binding activity. Involved in several processes, including embryonic morphogenesis; open tracheal system development; and regionalization. Acts upstream of with a positive effect on imaginal disc fusion, thorax closure. Located in cell leading edge; dense core granule lumen; and extracellular space. Colocalizes with cytoneme. Is expressed in several structures, including anterior-posterior subdivision of organism; compartment boundary; epithelium; imaginal disc; and wing vein. Used to study juvenile polyposis syndrome. Human ortholog(s) of this gene implicated in several diseases, including CAKUT (multiple); bone disease (multiple); cleft lip; hemochromatosis type 1; and orofacial cleft 11. Orthologous to human BMP2 (bone morphogenetic protein 2) and BMP4 (bone morphogenetic protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See dpp in Genome Data Viewer
    Location:
    22F1-22F3; 2-6 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2428372..2459823)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2428372..2459823)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44912 Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Tyrosine-GTA 1-2 Neighboring gene transfer RNA:Tyrosine-GTA 1-3

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables BMP receptor binding PubMed 
    enables collagen binding PubMed 
    enables cytokine activity  
    enables growth factor activity  
    enables heparin binding PubMed 
    enables morphogen activity PubMed 
    enables morphogen activity PubMed 
    enables morphogen activity PubMed 
    enables protein binding PubMed 
    enables protein heterodimerization activity PubMed 
    enables protein homodimerization activity PubMed 
    enables protein homodimerization activity PubMed 
    enables protein serine/threonine kinase activator activity PubMed 
    enables receptor ligand activity PubMed 
    Items 1 - 25 of 66
    Process Evidence Code Pubs
    involved_in BMP signaling pathway PubMed 
    involved_in BMP signaling pathway PubMed 
    involved_in BMP signaling pathway PubMed 
    involved_in Malpighian tubule morphogenesis PubMed 
    involved_in R8 cell fate specification PubMed 
    involved_in amnioserosa formation PubMed 
    involved_in anterior Malpighian tubule development PubMed 
    involved_in cardioblast differentiation PubMed 
    involved_in cell chemotaxis involved in Malpighian tubule morphogenesis PubMed 
    involved_in chorion-containing eggshell formation PubMed 
    involved_in compound eye morphogenesis PubMed 
    involved_in dorsal appendage formation PubMed 
    involved_in dorsal closure PubMed 
    involved_in dorsal/ventral axis specification PubMed 
    involved_in dorsal/ventral pattern formation PubMed 
    involved_in dorsal/ventral pattern formation PubMed 
    involved_in ectodermal cell fate specification PubMed 
    involved_in embryonic hindgut morphogenesis PubMed 
    involved_in epithelial cell migration, open tracheal system PubMed 
    involved_in eye-antennal disc development PubMed 
    involved_in eye-antennal disc morphogenesis PubMed 
    involved_in female germ-line stem cell population maintenance PubMed 
    involved_in follicle cell of egg chamber development PubMed 
    involved_in fusion cell fate specification PubMed 
    involved_in genital disc anterior/posterior pattern formation PubMed 
    involved_in genital disc development PubMed 
    involved_in genital disc sexually dimorphic development PubMed 
    involved_in germ cell development PubMed 
    involved_in germ cell migration PubMed 
    involved_in germ-line stem cell division PubMed 
    involved_in germ-line stem cell population maintenance PubMed 
    involved_in head morphogenesis PubMed 
    involved_in heart development PubMed 
    involved_in hemocyte development PubMed 
    involved_in hindgut morphogenesis PubMed 
    involved_in imaginal disc development PubMed 
    acts_upstream_of_positive_effect imaginal disc fusion, thorax closure PubMed 
    involved_in imaginal disc-derived wing morphogenesis PubMed 
    involved_in imaginal disc-derived wing vein morphogenesis PubMed 
    involved_in imaginal disc-derived wing vein specification PubMed 
    involved_in intestinal stem cell homeostasis PubMed 
    involved_in labial disc development PubMed 
    involved_in larval lymph gland hemocyte differentiation PubMed 
    involved_in lymph gland development PubMed 
    involved_in male germ-line stem cell population maintenance PubMed 
    involved_in maternal specification of dorsal/ventral axis, oocyte, soma encoded PubMed 
    involved_in mesoderm development PubMed 
    involved_in mesoderm development PubMed 
    involved_in negative regulation of gene expression PubMed 
    involved_in negative regulation of salivary gland boundary specification PubMed 
    involved_in pericardial nephrocyte differentiation PubMed 
    involved_in positive regulation of SMAD protein signal transduction PubMed 
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of imaginal disc growth PubMed 
    involved_in positive regulation of muscle organ development PubMed 
    involved_in progression of morphogenetic furrow involved in compound eye morphogenesis PubMed 
    involved_in regulation of cell differentiation PubMed 
    involved_in regulation of cell shape PubMed 
    involved_in regulation of imaginal disc growth PubMed 
    involved_in regulation of stem cell differentiation PubMed 
    involved_in regulation of tube diameter, open tracheal system PubMed 
    involved_in spectrosome organization PubMed 
    involved_in wing and notum subfield formation PubMed 
    involved_in wing disc pattern formation PubMed 
    involved_in wing disc pattern formation PubMed 
    involved_in zygotic specification of dorsal/ventral axis PubMed 
    Items 1 - 25 of 66
    Component Evidence Code Pubs
    located_in cell leading edge PubMed 
    colocalizes_with cytoneme PubMed 
    located_in dense core granule lumen PubMed 
    located_in extracellular region  
    is_active_in extracellular space  
    is_active_in extracellular space PubMed 
    located_in extracellular space PubMed 

    General protein information

    Preferred Names
    decapentaplegic
    Names
    CG9885-PA
    CG9885-PB
    CG9885-PC
    CG9885-PE
    Decapentaplegic/Bone morphogenetic protein
    Haplo-insufficient
    blink
    bone morphogenetic protein
    bone morphogenic protein
    dpp-PA
    dpp-PB
    dpp-PC
    dpp-PE
    heldout
    shortvein
    tegula

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2428372..2459823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057963.5 → NP_477311.1  decapentaplegic, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477311.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V009, P07713, P91651, Q6AWM1, Q8I0M7, Q8ITK4, Q9VQC6
      Related
      FBpp0077451
      Conserved Domains (2) summary
      smart00204
      Location:487 → 588
      TGFB; Transforming growth factor-beta (TGF-beta) family
      pfam00688
      Location:225 → 444
      TGFb_propeptide; TGF-beta propeptide
    2. NM_164485.2 → NP_722810.1  decapentaplegic, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722810.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V009, P07713, P91651, Q6AWM1, Q8I0M7, Q8ITK4, Q9VQC6
      Related
      FBpp0077452
      Conserved Domains (2) summary
      smart00204
      Location:487 → 588
      TGFB; Transforming growth factor-beta (TGF-beta) family
      pfam00688
      Location:225 → 444
      TGFb_propeptide; TGF-beta propeptide
    3. NM_164486.2 → NP_722811.1  decapentaplegic, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722811.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V009, P07713, P91651, Q6AWM1, Q8I0M7, Q8ITK4, Q9VQC6
      Related
      FBpp0077453
      Conserved Domains (2) summary
      smart00204
      Location:487 → 588
      TGFB; Transforming growth factor-beta (TGF-beta) family
      pfam00688
      Location:225 → 444
      TGFb_propeptide; TGF-beta propeptide
    4. NM_164488.2 → NP_722813.1  decapentaplegic, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722813.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V009, P07713, P91651, Q6AWM1, Q8I0M7, Q8ITK4, Q9VQC6
      Related
      FBpp0077455
      Conserved Domains (2) summary
      smart00204
      Location:487 → 588
      TGFB; Transforming growth factor-beta (TGF-beta) family
      pfam00688
      Location:225 → 444
      TGFb_propeptide; TGF-beta propeptide
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