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    dyl dusky-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38531, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dylprovided by FlyBase
    Official Full Name
    dusky-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0066365
    Locus tag
    Dmel_CG15013
    See related
    AllianceGenome:FB:FBgn0066365
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15013; Dmel\CG15013; Dyl
    Summary
    Predicted to be a structural constituent of chitin-based cuticle. Involved in several processes, including apical constriction; cell-matrix adhesion; and regulation of embryonic cell shape. Located in apical plasma membrane. Is expressed in several structures, including adult head; embryonic dorsal epidermis; embryonic head epidermis; gut section; and trichome. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dyl in Genome Data Viewer
    Location:
    64B1-64B1; 3-12 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4294004..4307718, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4294004..4307718, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Hexosaminidase 1 Neighboring gene uncharacterized protein Neighboring gene Ferredoxin 2 Neighboring gene claspin Neighboring gene Peroxisomal Membrane Protein 34 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phenotypic robustness conferred by apparently redundant transcriptional enhancers. Frankel N, et al. Nature, 2010 Jul 22. PMID 20512118, Free PMC Article
    2. Molecular analysis of the Drosophila miniature-dusky ( m-dy) gene complex: m-dy mRNAs encode transmembrane proteins with similarity to C. elegans cuticulin. DiBartolomeis SM, et al. Mol Genet Genomics, 2002 Jul. PMID 12172795
    3. Mechano-chemical enforcement of tendon apical ECM into nano-filaments during Drosophila flight muscle development. Chu WC, et al. Curr Biol, 2021 Apr 12. PMID 33545042
    4. Dusky-like functions as a Rab11 effector for the deposition of cuticle during Drosophila bristle development. Nagaraj R, et al. Development, 2012 Mar. PMID 22278919, Free PMC Article
    5. ChtVis-Tomato, a genetic reporter for in vivo visualization of chitin deposition in Drosophila. Sobala LF, et al. Development, 2015 Nov 15. PMID 26395478, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that Dyl functions as a Rab11 effector for mediating the attachment of the bristle cell membrane to chitin to establish a stable cuticle.
      Title: Dusky-like functions as a Rab11 effector for the deposition of cuticle during Drosophila bristle development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of chitin-based cuticle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in apical constriction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of embryonic cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dusky-like
    Names
    CG15013-PA
    CG15013-PB
    CG15013-PC
    Dusky-like
    dyl-PA
    dyl-PB
    dyl-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4294004..4307718 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168078.2 → NP_728979.1  dusky-like, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728979.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZE0
      Related
      FBpp0073197
      Conserved Domains (2) summary
      smart00241
      Location:90 → 345
      ZP; Zona pellucida (ZP) domain
      PHA03378
      Location:339 → 494
      PHA03378; EBNA-3B; Provisional

    2. NM_139633.3 → NP_647890.2  dusky-like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647890.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZE0
      Related
      FBpp0073198
      Conserved Domains (2) summary
      smart00241
      Location:90 → 345
      ZP; Zona pellucida (ZP) domain
      PHA03378
      Location:339 → 494
      PHA03378; EBNA-3B; Provisional

    3. NM_168079.2 → NP_728980.1  dusky-like, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728980.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZE0
      Related
      FBpp0073199
      Conserved Domains (2) summary
      smart00241
      Location:90 → 345
      ZP; Zona pellucida (ZP) domain
      PHA03378
      Location:339 → 494
      PHA03378; EBNA-3B; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q960I7 Q960I7
    Q9VZE0 Q9VZE0

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