Rbks ribokinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rbksprovided by RGD
Official Full Name: ribokinaseprovided by RGD
Primary source: RGD:1310064
See related: EnsemblRapid:ENSRNOG00000004710 AllianceGenome:RGD:1310064
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity and ribokinase activity. Predicted to be involved in pentose-phosphate shunt. Predicted to be located in nucleus. Predicted to be active in cytosol. Orthologous to human RBKS (ribokinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 37.7), Adrenal (RPKM 31.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q14

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (30467724..30544284)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (24747651..24824290)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (26051568..26128762)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

AI233177 (e-PCR)
- UniSTS:250115

BE097107 (e-PCR)
- UniSTS:244601

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ribokinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in D-ribose catabolic process	IEA Inferred from Electronic Annotation more info
involved_in carbohydrate phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in pentose-phosphate shunt	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ribokinase

NP_001102173.1

EC 2.7.1.15

XP_006239867.1

EC 2.7.1.15

XP_006239868.1

EC 2.7.1.15

XP_008762743.1

EC 2.7.1.15

XP_038968398.1

EC 2.7.1.15

XP_038968399.1

EC 2.7.1.15

XP_038968400.1

EC 2.7.1.15

XP_038968401.1

EC 2.7.1.15

XP_063118121.1

EC 2.7.1.15

XP_063118122.1

EC 2.7.1.15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108703.1 → NP_001102173.1 ribokinase

See identical proteins and their annotated locations for NP_001102173.1

Status: PROVISIONAL

Source sequence(s)

CH473947

UniProtKB/TrEMBL

A0A8I6G4T5, A6HA35

Conserved Domains (1) summary

TIGR02152
Location:23 → 319

D_ribokin_bact; ribokinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

30467724..30544284

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006239806.5 → XP_006239868.1 ribokinase isoform X3

Conserved Domains (1) summary

cl00192
Location:23 → 256

ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
XM_006239805.4 → XP_006239867.1 ribokinase isoform X2

Conserved Domains (1) summary

cl00192
Location:23 → 264

ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
XM_039112471.2 → XP_038968399.1 ribokinase isoform X5

Conserved Domains (1) summary

cl00192
Location:23 → 201

ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
XM_008764521.3 → XP_008762743.1 ribokinase isoform X1

Related

ENSRNOP00000006452.6, ENSRNOT00000006452.8

Conserved Domains (1) summary

cl00192
Location:23 → 266

ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
XM_063262051.1 → XP_063118121.1 ribokinase isoform X4
XM_063262052.1 → XP_063118122.1 ribokinase isoform X8
XM_039112470.2 → XP_038968398.1 ribokinase isoform X7

UniProtKB/TrEMBL

D3ZVU4

Related

ENSRNOP00000080640.2, ENSRNOT00000098615.2

Conserved Domains (1) summary

TIGR02152
Location:20 → 308

D_ribokin_bact; ribokinase
XM_039112473.2 → XP_038968401.1 ribokinase isoform X6

Conserved Domains (1) summary

cl00192
Location:1 → 170

ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
XM_039112472.2 → XP_038968400.1 ribokinase isoform X6

Conserved Domains (1) summary

cl00192
Location:1 → 170

ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...