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    Trmt112 tRNA methyltransferase activator subunit 11-2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293700, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trmt112provided by RGD
    Official Full Name
    tRNA methyltransferase activator subunit 11-2provided by RGD
    Primary source
    RGD:1309710
    See related
    EnsemblRapid:ENSRNOG00000073020 AllianceGenome:RGD:1309710
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309710
    Summary
    Predicted to enable protein heterodimerization activity; protein methyltransferase activity; and tRNA methyltransferase activator activity. Predicted to be involved in RNA metabolic process; peptidyl-glutamine methylation; and positive regulation of rRNA processing. Predicted to be located in nucleoplasm and perinuclear region of cytoplasm. Predicted to be part of tRNA (m2G10) methyltransferase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human TRMT112 (tRNA methyltransferase activator subunit 11-2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 438.4), Adrenal (RPKM 417.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Trmt112 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (213532507..213533360)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (204103298..204104151)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (222167927..222168780)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483961 Neighboring gene ATP synthase membrane subunit c locus 1 like 1 Neighboring gene peroxiredoxin 5 Neighboring gene estrogen related receptor, alpha Neighboring gene catsper channel auxiliary subunit zeta Neighboring gene uncharacterized LOC134483962 Neighboring gene potassium two pore domain channel subfamily K member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells. Metzger E, et al. Nat Struct Mol Biol, 2019 May. PMID 31061526
    2. Substrate Specificity of the HEMK2 Protein Glutamine Methyltransferase and Identification of Novel Substrates. Kusevic D, et al. J Biol Chem, 2016 Mar 18. PMID 26797129, Free PMC Article
    3. The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112. van Tran N, et al. Nucleic Acids Res, 2019 Sep 5. PMID 31328227, Free PMC Article
    4. The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis. Zorbas C, et al. Mol Biol Cell, 2015 Jun 1. PMID 25851604, Free PMC Article
    5. HemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1. Figaro S, et al. FEBS Lett, 2008 Jul 9. PMID 18539146

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA methyltransferase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptidyl-glutamine methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of rRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rRNA (guanine-N7)-methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rRNA methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation-coupled chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    multifunctional methyltransferase subunit TRM112-like protein
    Names
    tRNA methyltransferase 112 homolog
    tRNA methyltransferase subunit 11-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106330.2 → NP_001099800.1  multifunctional methyltransferase subunit TRM112-like protein

      See identical proteins and their annotated locations for NP_001099800.1

      Status: VALIDATED

      Source sequence(s)
      BP485075, DV720088
      UniProtKB/TrEMBL
      A6HZJ2, B2RYS9, B5DEM8
      Related
      ENSRNOP00000105490.1, ENSRNOT00000155932.1
      Conserved Domains (1) summary
      cd21089
      Location:2 → 118
      Trm112-like; eukaryotic tRNA methyltransferase 112, a partner protein of both rRNA/tRNA and protein methyltransferases, and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      213532507..213533360
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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