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    ens ensconsin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38491, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ensprovided by FlyBase
    Official Full Name
    ensconsinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0264693
    Locus tag
    Dmel_CG14998
    See related
    AllianceGenome:FB:FBgn0264693
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14998; Dm-308; Dmel\CG14998; Ens; ensc; swoosh
    Summary
    Enables microtubule binding activity. Involved in several processes, including larval somatic muscle development; microtubule cytoskeleton organization; and nuclear migration. Located in apical part of cell. Is expressed in adult head; oocyte; and organism. Orthologous to human MAP7D2 (MAP7 domain containing 2); MAP7D3 (MAP7 domain containing 3); and MAP7 (microtubule associated protein 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ens in Genome Data Viewer
    Location:
    64A7-64A7; 3-10 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4122907..4134550, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4122907..4134550, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Activated Cdc42 kinase Neighboring gene Chd64 Neighboring gene Replication factor C subunit 4 Neighboring gene Ras opposite

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The microtubule-binding protein ensconsin is an essential cofactor of kinesin-1. Barlan K, et al. Curr Biol, 2013 Feb 18. PMID 23394833, Free PMC Article
    2. Competition between microtubule-associated proteins directs motor transport. Monroy BY, et al. Nat Commun, 2018 Apr 16. PMID 29662074, Free PMC Article
    3. Drosophila Nesprin-1 controls glutamate receptor density at neuromuscular junctions. Morel V, et al. Cell Mol Life Sci, 2014 Sep. PMID 24492984, Free PMC Article
    4. Ensconsin-dependent changes in microtubule organization and LINC complex-dependent changes in nucleus-nucleus interactions result in quantitatively distinct myonuclear positioning defects. Collins MA, et al. Mol Biol Cell, 2021 Nov 1. PMID 34524872, Free PMC Article
    5. Deletion of endogenous Tau proteins is not detrimental in Drosophila. Burnouf S, et al. Sci Rep, 2016 Mar 15. PMID 26976084, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. At endogenous levels, Bsg25D positively regulates Ens activity during myonuclear positioning, but excess Bsg25D disrupts Ens localization and MT organization, with disastrous consequences for myonuclear positioning and muscle function.
      Title: The Drosophila Ninein homologue Bsg25D cooperates with Ensconsin in myonuclear positioning.
    2. Map7/7D1 and its Drosophila ortholog, Ensconsin show planar-polarized distribution in both mouse and fly epithelia, and Ensconsin influences proper localization of Drosophila Disheveled in pupal wing cells.
      Title: Map7/7D1 and Dvl form a feedback loop that facilitates microtubule remodeling and Wnt5a signaling.
    3. Ensconsin cooperates with its binding partner Kinesin-1 during interphase to trigger centrosome separation.
      Title: Ensconsin/Map7 promotes microtubule growth and centrosome separation in Drosophila neural stem cells.
    4. Ensconsin is essential for vesicle transport by kinesin-1 in cultured Drosophila S2 cells and primary neurons. Microtubule-binding domain of ensconsin is not required for this activity.
      Title: The microtubule-binding protein ensconsin is an essential cofactor of kinesin-1.
    5. our study suggests that ensconsin is an essential cofactor for all known functions of kinesin-1
      Title: The microtubule-binding protein ensconsin is an essential cofactor of kinesin-1.
    6. identification of the microtubule-associated protein ensconsin (Ens)/microtubule-associated protein 7 (MAP7) and kinesin heavy chain (Khc)/Kif5b as essential, evolutionarily conserved regulators of myonuclear positioning in Drosophila and cultured mammalian myotubes
      Title: MAP and kinesin-dependent nuclear positioning is required for skeletal muscle function.
    7. ensconsin promotes productive recruitment of Kinesin-1 to microtubules.
      Title: Drosophila ensconsin promotes productive recruitment of Kinesin-1 to microtubules.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in centrosome separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval somatic muscle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule polymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of microtubule-based movement IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of microtubule-based movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ensconsin
    Names
    CG14998-PA
    CG14998-PB
    CG14998-PC
    CG14998-PD
    CG14998-PE
    CG14998-PF
    CG14998-PG
    CG14998-PH
    CG14998-PI
    CG14998-PJ
    CG14998-PK
    CG14998-PL
    enconsin
    ens-PA
    ens-PB
    ens-PC
    ens-PD
    ens-PE
    ens-PF
    ens-PG
    ens-PH
    ens-PI
    ens-PJ
    ens-PK
    ens-PL
    swoosh

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4122907..4134550 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300004.1 → NP_001286933.1  ensconsin, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286933.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E6PBW7, Q8IRC0
      Conserved Domains (3) summary
      PTZ00121
      Location:18 → 130
      PTZ00121; MAEBL; Provisional
      PRK07003
      Location:284 → 477
      PRK07003; DNA polymerase III subunits gamma and tau; Validated
      pfam15927
      Location:581 → 620
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    2. NM_168062.3 → NP_728939.2  ensconsin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728939.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E6PBW7, Q8IRC0
      Conserved Domains (3) summary
      PTZ00121
      Location:18 → 130
      PTZ00121; MAEBL; Provisional
      PRK07003
      Location:284 → 477
      PRK07003; DNA polymerase III subunits gamma and tau; Validated
      pfam15927
      Location:581 → 620
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    3. NM_139604.2 → NP_647861.2  ensconsin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647861.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E6PBW7, Q8IRC1
      Conserved Domains (2) summary
      PRK07003
      Location:219 → 412
      PRK07003; DNA polymerase III subunits gamma and tau; Validated
      pfam15927
      Location:516 → 555
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    4. NM_001274474.1 → NP_001261403.1  ensconsin, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261403.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E6PBW7, F2FB68
      Conserved Domains (2) summary
      PRK07003
      Location:234 → 427
      PRK07003; DNA polymerase III subunits gamma and tau; Validated
      pfam15927
      Location:531 → 570
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    5. NM_001274473.1 → NP_001261402.1  ensconsin, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261402.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E6PBW7, M9PBN6
      Conserved Domains (3) summary
      PTZ00121
      Location:16 → 127
      PTZ00121; MAEBL; Provisional
      PRK07003
      Location:354 → 547
      PRK07003; DNA polymerase III subunits gamma and tau; Validated
      pfam15927
      Location:651 → 690
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    6. NM_001274471.1 → NP_001261400.1  ensconsin, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261400.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E6PBW7, M9PE93
      Conserved Domains (3) summary
      PTZ00121
      Location:18 → 128
      PTZ00121; MAEBL; Provisional
      PRK07003
      Location:401 → 594
      PRK07003; DNA polymerase III subunits gamma and tau; Validated
      pfam15927
      Location:698 → 737
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    7. NM_001274470.1 → NP_001261399.1  ensconsin, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261399.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E6PBW7, M9PEK8
      Conserved Domains (2) summary
      PRK07003
      Location:319 → 512
      PRK07003; DNA polymerase III subunits gamma and tau; Validated
      pfam15927
      Location:616 → 655
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    8. NM_001274472.1 → NP_001261401.1  ensconsin, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261401.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHB1
      Conserved Domains (3) summary
      PTZ00121
      Location:16 → 127
      PTZ00121; MAEBL; Provisional
      PRK07003
      Location:486 → 679
      PRK07003; DNA polymerase III subunits gamma and tau; Validated
      pfam15927
      Location:783 → 822
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    9. NM_168061.2 → NP_728938.2  ensconsin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728938.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E6PBW7, Q9VZI0
      Conserved Domains (2) summary
      PRK07003
      Location:237 → 430
      PRK07003; DNA polymerase III subunits gamma and tau; Validated
      pfam15927
      Location:534 → 573
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    10. NM_168063.2 → NP_728940.2  ensconsin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728940.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E6PBW7, Q8IRB9
      Conserved Domains (1) summary
      pfam05672
      Location:662 → 802
      MAP7; MAP7 (E-MAP-115) family

    11. NM_168064.2 → NP_728941.2  ensconsin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728941.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E6PBW7, Q6NQY4, Q9I7T2
      Conserved Domains (2) summary
      PRK07003
      Location:273 → 466
      PRK07003; DNA polymerase III subunits gamma and tau; Validated
      pfam15927
      Location:570 → 609
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    12. NM_001104028.2 → NP_001097498.1  ensconsin, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097498.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNK1
      Conserved Domains (1) summary
      pfam05672
      Location:920 → 1060
      MAP7; MAP7 (E-MAP-115) family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JNK1 A8JNK1
    F2FB68 F2FB68
    M9PBN6 M9PBN6
    M9PE93 M9PE93
    M9PEK8 M9PEK8
    M9PHB1 M9PHB1
    Q8IRB9 Q8IRB9
    Q8IRC0 Q8IRC0
    Q8IRC1 Q8IRC1
    Q9I7T2 Q9I7T2
    Q9VZI0 Q9VZI0

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