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    SCAR SCAR [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34519, updated on 9-Dec-2024

    Summary

    Official Symbol
    SCARprovided by FlyBase
    Official Full Name
    SCARprovided by FlyBase
    Primary source
    FLYBASE:FBgn0041781
    Locus tag
    Dmel_CG4636
    See related
    AllianceGenome:FB:FBgn0041781
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:SD02991; CG4636; D-SCAR; Dmel\CG4636; DmSCAR; Dscar; dWAVE; DWave; l(2)k03107; l(2)k13811; scar; Scar; scar/wave; SCAR/WAVE; wave; Wave; WAVE; WAVE/SCAR
    Summary
    Predicted to enable Arp2/3 complex binding activity and protein kinase A regulatory subunit binding activity. Involved in several processes, including actin cytoskeleton organization; generation of neurons; and positive regulation of cellular component organization. Located in several cellular components, including apical part of cell; basal part of cell; and nucleus. Part of SCAR complex. Is expressed in several structures, including adult head; indirect flight muscle cell; presumptive embryonic/larval central nervous system; and tract. Orthologous to several human genes including WASF3 (WASP family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SCAR in Genome Data Viewer
    Location:
    32C1-32C1; 2-44 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10976772..10982395)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10976772..10982395)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene abnormal oocyte Neighboring gene ATP synthase, subunit G Neighboring gene P-element induced wimpy testis Neighboring gene uncharacterized protein Neighboring gene Tubulin tyrosine ligase-like 4A Neighboring gene aubergine

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables Arp2/3 complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase A regulatory subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in actin filament-based process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in axon extension involved in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in axonal fasciculation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell adhesion mediated by integrin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell projection assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in compound eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cortical actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in female germline ring canal stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in myoblast fusion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of actin nucleation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of filopodium assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of lamellipodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of actin nucleation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SCAR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SCAR complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of SCAR complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basal part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    SCAR
    Names
    CG4636-PA
    CG4636-PB
    CG4636-PC
    CG4636-PD
    CG4636-PE
    CG4636-PF
    SCAR-PA
    SCAR-PB
    SCAR-PC
    SCAR-PD
    SCAR-PE
    SCAR-PF
    WASP family verprolin-homologous protein
    scar
    suppressor of cAMP receptors
    suppressor of cAR
    suppressor of cyclic AMP receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10976772..10982395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273439.2NP_001260368.1  SCAR, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260368.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1C3C5, F2FB81
    2. NM_001298895.1NP_001285824.1  SCAR, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285824.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1C3C5, X2J5L4
    3. NM_001259038.3NP_001245967.1  SCAR, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245967.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1C3C5, M9NCT2
    4. NM_001273440.2NP_001260369.1  SCAR, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260369.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1C3C5, M9PCP4
    5. NM_001259037.3NP_001245966.1  SCAR, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245966.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1C3C5, H5V8D0
    6. NM_135633.4NP_609477.1  SCAR, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609477.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1C3C5, Q9VKM2
      Related
      FBpp0079737