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    Cand1 Cullin-associated and neddylation-dissociated 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34403, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cand1provided by FlyBase
    Official Full Name
    Cullin-associated and neddylation-dissociated 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0027568
    Locus tag
    Dmel_CG5366
    See related
    AllianceGenome:FB:FBgn0027568
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH07774; CAND1; CG5366; dmCAND1; Dmel\CG5366
    Summary
    Involved in negative regulation of protein neddylation and regulation of protein stability. Predicted to be active in nucleus. Is expressed in adult head. Orthologous to several human genes including CAND1 (cullin associated and neddylation dissociated 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cand1 in Genome Data Viewer
    Location:
    31D10-31D10; 2-41 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10358134..10362707, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10358134..10362707, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Cathepsin L4 Neighboring gene Caseinolytic protease proteolytic subunit Neighboring gene pimples Neighboring gene lowfat

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis CAND1, an unmodified CUL1-interacting protein, is involved in multiple developmental pathways controlled by ubiquitin/proteasome-mediated protein Degradation. Feng S, et al. Plant Cell, 2004 Jul. PMID 15208391, Free PMC Article
    2. Involvement of CUL4 ubiquitin E3 ligases in regulating CDK inhibitors Dacapo/p27Kip1 and cyclin E degradation. Higa LA, et al. Cell Cycle, 2006 Jan. PMID 16322693
    3. Neddylation activity modulates the neurodegeneration associated with fragile X associated tremor/ataxia syndrome (FXTAS) through regulating Sima. Lin Y, et al. Neurobiol Dis, 2020 Sep. PMID 32653676
    4. Drosophila Cand1 regulates Cullin3-dependent E3 ligases by affecting the neddylation of Cullin3 and by controlling the stability of Cullin3 and adaptor protein. Kim SH, et al. Dev Biol, 2010 Oct 15. PMID 20691177
    5. Akirin proteins in development and disease: critical roles and mechanisms of action. Bosch PJ, et al. Cell Mol Life Sci, 2020 Nov. PMID 32361777, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila Cand1 (encoded by CG5366) regulates Cullin3-dependent E3 ligases by affecting the neddylation of Cullin3 and by controlling the stability of Cullin3 and adaptor protein
      Title: Drosophila Cand1 regulates Cullin3-dependent E3 ligases by affecting the neddylation of Cullin3 and by controlling the stability of Cullin3 and adaptor protein.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SCF complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein neddylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Cullin-associated and neddylation-dissociated 1
    Names
    CG5366-PA
    CG5366-PB
    Cand1-PA
    Cand1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10358134..10362707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273404.1 → NP_001260333.1  Cullin-associated and neddylation-dissociated 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260333.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q4QQA6, Q9VKY2, Q9Y127
      UniProtKB/TrEMBL
      M9PB90
      Conserved Domains (3) summary
      pfam08623
      Location:1056 → 1218
      TIP120; TATA-binding protein interacting (TIP20)
      pfam13513
      Location:147 → 200
      HEAT_EZ; HEAT-like repeat
      sd00044
      Location:982 → 1011
      HEAT; HEAT repeat [structural motif]

    2. NM_135545.3 → NP_609389.1  Cullin-associated and neddylation-dissociated 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609389.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q4QQA6, Q9VKY2, Q9Y127
      UniProtKB/TrEMBL
      M9PB90
      Related
      FBpp0079643
      Conserved Domains (3) summary
      pfam08623
      Location:1056 → 1218
      TIP120; TATA-binding protein interacting (TIP20)
      pfam13513
      Location:147 → 200
      HEAT_EZ; HEAT-like repeat
      sd00044
      Location:982 → 1011
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PB90 M9PB90
    Q7KMK9 Q7KMK9
    Q9VKY2.1 Q9VKY2

    Gene LinkOut

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