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    Sara Smad anchor for receptor activation [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44263, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Saraprovided by FlyBase
    Official Full Name
    Smad anchor for receptor activationprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026369
    Locus tag
    Dmel_CG15667
    See related
    AllianceGenome:FB:FBgn0026369
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15667; Dmel\CG15667; dSARA; sara; SARA
    Summary
    Enables protein phosphatase 1 binding activity. Involved in asymmetric stem cell division; intestinal stem cell homeostasis; and stem cell fate determination. Located in early endosome. Orthologous to human ZFYVE16 (zinc finger FYVE-type containing 16) and ZFYVE9 (zinc finger FYVE-type containing 9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sara in Genome Data Viewer
    Location:
    57E6-57E6; 2-95 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21481927..21487107)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17369432..17374612)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene acyl-Coenzyme A oxidase at 57D proximal Neighboring gene acyl-Coenzyme A oxidase at 57D distal Neighboring gene Syndecan Neighboring gene FK506-binding protein 14 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Target-selected mutant screen by TILLING in Drosophila. Winkler S, et al. Genome Res, 2005 May. PMID 15867432, Free PMC Article
    2. Cell biology. Sara splits the signal. Knoblich JA. Science, 2006 Nov 17. PMID 17110561
    3. Intracellular signaling: Fleshing out the TGFbeta pathway. Padgett RW. Curr Biol, 1999 Jun 3. PMID 10359694
    4. Uninflatable and Notch control the targeting of Sara endosomes during asymmetric division. Loubéry S, et al. Curr Biol, 2014 Sep 22. PMID 25155514
    5. Disorder in a target for the smad2 mad homology 2 domain and its implications for binding and specificity. Chong PA, et al. J Biol Chem, 2004 Sep 24. PMID 15231848

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. upon phosphorylation of Sara, endosomes detach from the spindle during pIIa targeting.
      Title: Sara phosphorylation state controls the dispatch of endosomes from the central spindle during asymmetric division.
    2. Notch binds Uninflatable, and both traffic together through Sara endosomes, which is essential to direct asymmetric endosomes motility and Notch-dependent cell fate assignation.
      Title: Uninflatable and Notch control the targeting of Sara endosomes during asymmetric division.
    3. Sara itself contributes to the control of the intestinal stem cells asymmetric division.
      Title: Sara endosomes and the asymmetric division of intestinal stem cells.
    4. asymmetric targeting of Delta and Notch-containing Sara endosomes will increase Notch signalling in sensory organ precursor daughter cell, pIIa, and decrease it in pIIb
      Title: Directional Delta and Notch trafficking in Sara endosomes during asymmetric cell division.
    5. PP1 binds Sara and negatively regulates Dpp signaling in Drosophila melanogaster.
      Title: PP1 binds Sara and negatively regulates Dpp signaling in Drosophila melanogaster.
    6. During mitosis, Sara endosomes associate with the spindle machinery to segregate into the two daughter cells, daughter cells thereby inherited equal amounts of signaling molecules and retained the Dpp signaling levels of the mother cell
      Title: Sara endosomes and the maintenance of Dpp signaling levels across mitosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase 1 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in asymmetric stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intestinal stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in stem cell fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    smad anchor for receptor activation
    Names
    CG15667-PA
    Sara-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21481927..21487107
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079990.3 → NP_524729.2  smad anchor for receptor activation [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524729.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K9H6, Q960V6
      Related
      FBpp0071564
      Conserved Domains (3) summary
      cd15729
      Location:522 → 589
      FYVE_endofin; FYVE domain found in endofin and similar proteins
      pfam11409
      Location:614 → 650
      SARA; Smad anchor for receptor activation (SARA)
      pfam11979
      Location:959 → 1321
      DUF3480; Domain of unknown function (DUF3480)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K9H6 Q7K9H6
    Q960V6 Q960V6

    Gene LinkOut

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