Rnf146 Ring finger protein 146 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rnf146provided by FlyBase
Official Full Name: Ring finger protein 146provided by FlyBase
Primary source: FLYBASE:FBgn0036897
Locus tag: Dmel_CG8786
See related: AllianceGenome:FB:FBgn0036897
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:GM01527; CG8786; Dmel\CG8786; DRNF146; Iduna; RNF146
Summary: Enables ubiquitin protein ligase activity. Involved in several processes, including positive regulation of canonical Wnt signaling pathway; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and protein destabilization. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Orthologous to human RNF146 (ring finger protein 146). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 76B10-76B11; 3-45 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (19637207..19642816, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (19630307..19635916, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Iduna-mediated regulation of Axin proteolysis is essential for tissue homeostasis in the Drosophila midgut
Title: Axin proteolysis by Iduna is required for the regulation of stem cell proliferation and intestinal homeostasis in Drosophila.
Rnf146 and Tnks function in the same proteolysis pathway in vivo. Rnf146 promotes Wingless signaling in multiple developmental contexts by buffering Axin levels.
Title: A Context-Dependent Role for the RNF146 Ubiquitin Ligase in Wingless/Wnt Signaling in Drosophila.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables poly-ADP-D-ribose binding	IBA Inferred from Biological aspect of Ancestor more info
enables poly-ADP-D-ribose binding	IEA Inferred from Electronic Annotation more info
enables poly-ADP-D-ribose binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of negative regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein destabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ring finger protein 146

Names: CG8786-PB; CG8786-PC; CG8786-PF; CG8786-PG; Rnf146-PB; Rnf146-PC; Rnf146-PF; Rnf146-PG; iduna

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

19637207..19642816 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001144507.3 → NP_001137979.2 ring finger protein 146, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001137979.2

Status: REVIEWED

UniProtKB/TrEMBL

B7Z077, B7Z078

Conserved Domains (2) summary

smart00678
Location:192 → 264

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd00162
Location:123 → 165

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
NM_140881.4 → NP_649138.2 ring finger protein 146, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_649138.2

Status: REVIEWED

UniProtKB/TrEMBL

Q8SZQ1, Q9VW25

Related

FBpp0074730

Conserved Domains (2) summary

smart00678
Location:192 → 264

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd00162
Location:123 → 165

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
NM_001144506.3 → NP_001137978.1 ring finger protein 146, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001137978.1

Status: REVIEWED

UniProtKB/TrEMBL

B7Z077, B7Z078

Conserved Domains (2) summary

smart00678
Location:192 → 264

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd00162
Location:123 → 165

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
NM_001144508.3 → NP_001137980.2 ring finger protein 146, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001137980.2

Status: REVIEWED

UniProtKB/TrEMBL

B7Z083, D4G7C1

Conserved Domains (2) summary

cd00162
Location:123 → 165

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam02825
Location:191 → 219

WWE; WWE domain