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    thrC threonine synthase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945198, updated on 3-Dec-2024

    Summary

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    Official Symbol
    thrC
    Official Full Name
    threonine synthase
    Primary source
    ECOCYC:EG11000
    Locus tag
    b0004
    See related
    ASAP:ABE-0000012
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0004
    Summary
    Threonine synthase (ThrC) carries out the second step in the biosynthesis of threonine from homoserine, and the final step in overall threonine biosynthesis. [More information is available at EcoCyc: EG11000].
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    Genomic context

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    Sequence:
    NC_000913.3 (3734..5020)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene fused aspartate kinase/homoserine dehydrogenase 1 Neighboring gene homoserine kinase Neighboring gene DUF2502 domain-containing protein YaaX Neighboring gene DNA binding and peroxide stress response protein YaaA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Threonine synthase of Escherichia coli: inhibition by classical and slow-binding analogues of homoserine phosphate. Farrington GK, et al. Arch Biochem Biophys, 1993 Nov 15. PMID 7902068
    2. Mechanisms of interaction of Escherichia coli threonine synthase with substrates and inhibitors. Laber B, et al. Biochemistry, 1994 Mar 22. PMID 7907888
    3. Construction and expression of a hybrid plasmid containing the Escherichia coli thrA and thrB genes. Cossart P, et al. Mol Gen Genet, 1979 Aug. PMID 390305
    4. Interaction of aspartate and aspartate-derived antimetabolites with the enzymes of the threonine biosynthetic pathway of Escherichia coli. Shames SL, et al. J Biol Chem, 1984 Dec 25. PMID 6150934
    5. PROSITE: a dictionary of sites and patterns in proteins. Bairoch A. Nucleic Acids Res, 1992 May 11. PMID 1598232, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: '98 Escherichia coli SWISS-2DPAGE database update.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables threonine synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables threonine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in threonine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within threonine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    threonine synthase
    NP_414545.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3734..5020
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414545.1 threonine synthase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414545.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7EFT0
      Conserved Domains (1) summary
      PRK09225
      Location:1 → 428
      PRK09225; threonine synthase; Validated
    Nucleotide Protein
    Heading Accession and Version

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