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    msrA methionine sulfoxide reductase A [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948734, updated on 3-Dec-2024

    Summary

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    Official Symbol
    msrA
    Official Full Name
    methionine sulfoxide reductase A
    Primary source
    ECOCYC:EG11433
    Locus tag
    b4219
    See related
    ASAP:ABE-0013804
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4215; pms; pmsR
    Summary
    MsrA exhibits methionine sulfoxide reductase activity in vitro (Km of 120 micromolar) . [More information is available at EcoCyc: EG11433].
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    Genomic context

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    Sequence:
    NC_000913.3 (4441538..4442176, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene stringent response modulator YtfK Neighboring gene putative cadaverine/putrescine exporter Neighboring gene translocation and assembly module subunit TamA Neighboring gene translocation and assembly module subunit TamB Neighboring gene gamma-glutamylamine cyclotransferase family protein YtfP

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning, sequencing, and expression of the Escherichia coli peptide methionine sulfoxide reductase gene. Rahman MA, et al. J Biol Chem, 1992 Aug 5. PMID 1386361
    2. E. coli methionine sulfoxide reductase with a truncated N terminus or C terminus, or both, retains the ability to reduce methionine sulfoxide. Boschi-Muller S, et al. Protein Sci, 2001 Nov. PMID 11604533, Free PMC Article
    3. Peptide methionine sulfoxide reductase from Escherichia coli and Mycobacterium tuberculosis protects bacteria against oxidative damage from reactive nitrogen intermediates. St John G, et al. Proc Natl Acad Sci U S A, 2001 Aug 14. PMID 11481433, Free PMC Article
    4. (1)H, (13)C and (15)N resonance assignment of the reduced form of methionine sulfoxide reductase A from Escherichia coli. Coudevylle N, et al. J Biomol NMR, 2004 Nov. PMID 15756465
    5. Crystal structure of the Escherichia coli peptide methionine sulphoxide reductase at 1.9 A resolution. Tête-Favier F, et al. Structure, 2000 Nov 15. PMID 11080639

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that small RNA (sRNA) RyhB controls iron metabolism and directly pairs with the 5'UTR region of msrB at two distinct sites, but msrA expression is not sensitive to changes in iron availability.
      Title: The sRNA RyhB regulates the synthesis of the Escherichia coli methionine sulfoxide reductase MsrB but not MsrA.
    2. N-terminus verified by Edman degradation on mature peptide
      Title: Cloning, sequencing, and expression of the Escherichia coli peptide methionine sulfoxide reductase gene.
    3. MsrA and MsrB are required to repair Ffh oxidized by reactive oxygen species produced by aerobic metabolism, establishing an as-yet undescribed link between protein targeting and oxidation
      Title: Methionine sulfoxide reductases protect Ffh from oxidative damages in Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables L-methionine-(S)-S-oxide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-methionine-(S)-S-oxide reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-methionine:thioredoxin-disulfide S-oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables peptide-methionine (S)-S-oxide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide-methionine (S)-S-oxide reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptide-methionine (S)-S-oxide reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to oxidative stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    methionine sulfoxide reductase A
    NP_418640.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4441538..4442176 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418640.1 methionine sulfoxide reductase A [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418640.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7JZP9
      Conserved Domains (1) summary
      PRK00058
      Location:1 → 212
      PRK00058; peptide-methionine (S)-S-oxide reductase MsrA
    Nucleotide Protein
    Heading Accession and Version

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