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    flgM anti-sigma factor for FliA (sigma(28)) [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946684, updated on 17-Dec-2024

    Summary

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    Official Symbol
    flgM
    Official Full Name
    anti-sigma factor for FliA (sigma(28))
    Primary source
    ECOCYC:G369
    Locus tag
    b1071
    See related
    ASAP:ABE-0003634
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1056
    Summary
    Flk prevents premature FlgM secretion. [More information is available at EcoGene: EG12664]. FlgM function has been extensively studied in Salmonella typhimurium. [More information is available at EcoCyc: G369].
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    Genomic context

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    Sequence:
    NC_000913.3 (1129835..1130128, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene lipid II flippase MurJ Neighboring gene flagellar biosynthesis protein FlgN Neighboring gene flagellar basal body P-ring formation protein FlgA Neighboring gene flagellar basal-body rod protein FlgB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel transcriptional regulation mechanism in the flagellar regulon of Salmonella typhimurium: an antisigma factor inhibits the activity of the flagellum-specific sigma factor, sigma F. Ohnishi K, et al. Mol Microbiol, 1992 Nov. PMID 1453955
    2. Sensing structural intermediates in bacterial flagellar assembly by export of a negative regulator. Hughes KT, et al. Science, 1993 Nov 19. PMID 8235660
    3. FlgM gains structure in living cells. Dedmon MM, et al. Proc Natl Acad Sci U S A, 2002 Oct 1. PMID 12271132, Free PMC Article
    4. Stochastic assembly of chemoreceptor clusters in Escherichia coli. Thiem S, et al. Mol Microbiol, 2008 Jun. PMID 18476921
    5. A Salmonella typhimurium virulence gene linked to flg. Carsiotis M, et al. Infect Immun, 1989 Nov. PMID 2680969, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FlgM modulates FliA proteolysis
      Title: Cellular levels and activity of the flagellar sigma factor FliA of Escherichia coli are controlled by FlgM-modulated proteolysis.
    2. A complex of E. coli flagellar and chemotaxis-specific sigma factor 28 bound to the 28-binding region of its antisigma factor FlgM has been crystallized.
      Title: Preparation and preliminary X-ray diffraction analysis of crystals of bacterial flagellar sigma factor sigma 28 in complex with the sigma 28-binding region of its antisigma factor, FlgM.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sigma factor antagonist activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in bacterial-type flagellum organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    anti-sigma factor for FliA (sigma(28))

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1129835..1130128 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415589.1 anti-sigma factor for FliA (sigma(28)) [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415589.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1PVA3
      Conserved Domains (1) summary
      PRK10810
      Location:1 → 97
      PRK10810; anti-sigma-28 factor FlgM
    Nucleotide Protein
    Heading Accession and Version

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