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    uup ATP-binding protein Uup [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945566, updated on 3-Dec-2024

    Summary

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    Official Symbol
    uup
    Official Full Name
    ATP-binding protein Uup
    Primary source
    ECOCYC:G6489
    Locus tag
    b0949
    See related
    ASAP:ABE-0003213
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0940; ycbH; ycbI
    Summary
    Has two ABC ATPase domains; ATPase activity is essential for function. [More information is available at EcoGene: EG13134]. Uup is a cytosolic ATP-binding cassette (ABC) protein . [More information is available at EcoCyc: G6489].
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    Genomic context

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    Sequence:
    NC_000913.3 (1009964..1011871)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene cell division protein ZapC Neighboring gene 6-N-hydroxylaminopurine resistance protein Neighboring gene fused 23S rRNA m(2)G2445 methyltransferase and 23S rRNA m(7)G2069 methyltransferase Neighboring gene intermembrane transport protein PqiA Neighboring gene intermembrane transport protein PqiB Neighboring gene intermembrane transport lipoprotein PqiC

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C-terminal domain of the Uup ATP-binding cassette ATPase is an essential folding domain that binds to DNA. Burgos Zepeda MY, et al. Biochim Biophys Acta, 2010 Apr. PMID 19948254
    2. Deletion of the Escherichia coli uup gene encoding a protein of the ATP binding cassette superfamily affects bacterial competitiveness. Murat D, et al. Res Microbiol, 2008 Nov-Dec. PMID 18848624
    3. Sequence analysis of twin ATP binding cassette proteins involved in translational control, antibiotic resistance, and ribonuclease L inhibition. Kerr ID. Biochem Biophys Res Commun, 2004 Feb 27. PMID 15013441
    4. ATP hydrolysis is essential for the function of the Uup ATP-binding cassette ATPase in precise excision of transposons. Murat D, et al. J Biol Chem, 2006 Mar 10. PMID 16407313
    5. Frequent template switching in postreplication gaps: suppression of deleterious consequences by the Escherichia coli Uup and RadD proteins. Romero ZJ, et al. Nucleic Acids Res, 2020 Jan 10. PMID 31665437, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Resolving Toxic DNA repair intermediates in every E. coli replication cycle: critical roles for RecG, Uup and RadD.
      Title: Resolving Toxic DNA repair intermediates in every E. coli replication cycle: critical roles for RecG, Uup and RadD.
    2. RadD protein suppresses crossovers, and Uup prevents nucleoid mis-segregation during Dna replication of defective DNA sequences.
      Title: Frequent template switching in postreplication gaps: suppression of deleterious consequences by the Escherichia coli Uup and RadD proteins.
    3. compared the DNA binding activities of three versions of the protein (Uup, UupDeltaCTD and CTD) by an electrophoretic mobility shift assay. CTD is able to bind DNA although less efficiently than intact Uup and UupDeltaCTD (C-terminal domain).
      Title: C-terminal domain of the Uup ATP-binding cassette ATPase is an essential folding domain that binds to DNA.
    4. Deletion of the uup gene, which encodes a soluble ATP binding cassette (ABC) ATPase, renders the mutant strain sensitive to its parent when they are grown together in the same medium.
      Title: Deletion of the Escherichia coli uup gene encoding a protein of the ATP binding cassette superfamily affects bacterial competitiveness.
    5. ATP hydrolysis at the two ATP-binding cassette domains is strictly coordinated and is essential for the cytosolic ATP-binding cassette (ABC) ATPase function of Uup in vivo.
      Title: ATP hydrolysis is essential for the function of the Uup ATP-binding cassette ATPase in precise excision of transposons.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within postreplication repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ATP-binding protein Uup

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1009964..1011871
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415469.1 ATP-binding protein Uup [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415469.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7JS95, A0AAI9GXX6
      Conserved Domains (1) summary
      PRK11147
      Location:1 → 635
      PRK11147; ABC transporter ATPase component; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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