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    mglB D-galactose/methyl-galactoside ABC transporter periplasmic binding protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 949041, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mglB
    Official Full Name
    D-galactose/methyl-galactoside ABC transporter periplasmic binding protein
    Primary source
    ECOCYC:EG10593
    Locus tag
    b2150
    See related
    ASAP:ABE-0007108
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2143
    Summary
    MglB binds D-galactose and D-glucose and mediates chemotaxis through the Trg chemoreceptor. [More information is available at EcoGene: EG10593]. MglB is the periplasmic binding component of the galactose ABC transporter. [More information is available at EcoCyc: EG10593].
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    Genomic context

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    Sequence:
    NC_000913.3 (2239350..2240348, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene D-galactose/methyl-galactoside ABC transporter membrane subunit Neighboring gene D-galactose/methyl-galactoside ABC transporter ATP binding subunit Neighboring gene DNA-binding transcriptional dual regulator GalS Neighboring gene DUF418 domain-containing protein YeiB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The amino acid sequence of the D-galactose-binding protein from Escherichia coli B/r. Mahoney WC, et al. J Biol Chem, 1981 May 10. PMID 7012152
    2. A piezoelectric quartz crystal biosensor: the use of two single cysteine mutants of the periplasmic Escherichia coli glucose/galactose receptor as target proteins for the detection of glucose. Carmon KS, et al. Biochemistry, 2004 Nov 9. PMID 15518575
    3. A novel calcium binding site in the galactose-binding protein of bacterial transport and chemotaxis. Vyas NK, et al. Nature, 1987 Jun 18-24. PMID 3600760
    4. The role of calcium in the conformational dynamics and thermal stability of the D-galactose/D-glucose-binding protein from Escherichia coli. Herman P, et al. Proteins, 2005 Oct 1. PMID 16080150
    5. Change in rigidity in the activated form of the glucose/galactose receptor from Escherichia coli: a phenomenon that will be key to the development of biosensors. Sokolov I, et al. Biophys J, 2006 Feb 1. PMID 16284260, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carbohydrate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chemotaxis EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within galactose transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in galactose transmembrane transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within methylgalactoside transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in outer membrane-bounded periplasmic space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in outer membrane-bounded periplasmic space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    D-galactose/methyl-galactoside ABC transporter periplasmic binding protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2239350..2240348 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416655.1 D-galactose/methyl-galactoside ABC transporter periplasmic binding protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416655.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A793GD59
      Conserved Domains (1) summary
      PRK15395
      Location:2 → 331
      PRK15395; galactose/glucose ABC transporter substrate-binding protein MglB
    Nucleotide Protein
    Heading Accession and Version

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