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    emtA lytic murein transglycosylase E [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945655, updated on 17-Dec-2024

    Summary

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    Official Symbol
    emtA
    Official Full Name
    lytic murein transglycosylase E
    Primary source
    ECOCYC:G6622
    Locus tag
    b1193
    See related
    ASAP:ABE-0004006
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1181; mltE; sltZ; ycgP
    Summary
    First 15 aa are a type II signal peptide. [More information is available at EcoGene: EG13897]. EmtA is a lytic endotransglycosylase which is expressed in Escherichia coli as a membrane-bound lipoprotein. [More information is available at EcoCyc: G6622].
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    Genomic context

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    Sequence:
    NC_000913.3 (1243180..1243791)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YmgM Neighboring gene putative K(+):H(+) antiporter Neighboring gene murein tetrapeptide carboxypeptidase Neighboring gene flagellar brake protein YcgR Neighboring gene PF04226 family protein YmgE

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Structural Dissection of the Active Site of the Lytic Transglycosylase MltE from Escherichia coli. Dik DA, et al. Biochemistry, 2018 Oct 23. PMID 30256085
    2. Mechanism of the Escherichia coli MltE lytic transglycosylase, the cell-wall-penetrating enzyme for Type VI secretion system assembly. Byun B, et al. Sci Rep, 2018 Mar 7. PMID 29515200, Free PMC Article
    3. On the mechanism of peptidoglycan binding and cleavage by the endo-specific lytic transglycosylase MltE from Escherichia coli. Fibriansah G, et al. Biochemistry, 2012 Nov 13. PMID 23075328
    4. High-resolution crystal structure of MltE, an outer membrane-anchored endolytic peptidoglycan lytic transglycosylase from Escherichia coli. Artola-Recolons C, et al. Biochemistry, 2011 Apr 5. PMID 21341761, Free PMC Article
    5. Membrane-bound lytic endotransglycosylase in Escherichia coli. Kraft AR, et al. J Bacteriol, 1998 Jul. PMID 9642199, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mechanism of the Escherichia coli MltE lytic transglycosylase, the cell-wall-penetrating enzyme for Type VI secretion system assembly.
      Title: Mechanism of the Escherichia coli MltE lytic transglycosylase, the cell-wall-penetrating enzyme for Type VI secretion system assembly.
    2. A Structural Dissection of the Active Site of the Lytic Transglycosylase MltE from Escherichia coli.
      Title: A Structural Dissection of the Active Site of the Lytic Transglycosylase MltE from Escherichia coli.
    3. results indicate that catalysis of glycosidic bond cleavage by MltE proceeds via distortion toward a sofa-like conformation of the N-acetylmuramic acid sugar ring at subsite -1 and by anchimeric assistance of the sugar's N-acetyl group.
      Title: On the mechanism of peptidoglycan binding and cleavage by the endo-specific lytic transglycosylase MltE from Escherichia coli.
    4. high-resolution (2.0 A) crystal structure of MltE: molecular model; substrate specificity; proposed catalytic mechanism as endolytic enzyme; membrane anchor; comparison with molecular model of Slt70
      Title: High-resolution crystal structure of MltE, an outer membrane-anchored endolytic peptidoglycan lytic transglycosylase from Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables carbon-oxygen lyase activity, acting on polysaccharides IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lytic endotransglycosylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lytic endotransglycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lytic transglycosylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lytic transglycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell division EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in cell wall macromolecule catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell outer membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lytic murein transglycosylase E

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1243180..1243791
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415711.2 lytic murein transglycosylase E [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415711.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AKS7
      Conserved Domains (1) summary
      PRK15470
      Location:1 → 203
      emtA; membrane-bound lytic murein transglycosylase EmtA
    Nucleotide Protein
    Heading Accession and Version

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