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    fabH 3-oxoacyl-[acyl carrier protein] synthase 3 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946003, updated on 3-Dec-2024

    Summary

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    Official Symbol
    fabH
    Official Full Name
    3-oxoacyl-[acyl carrier protein] synthase 3
    Primary source
    ECOCYC:EG10277
    Locus tag
    b1091
    See related
    ASAP:ABE-0003696
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1077
    Summary
    fabH is an essential gene. [More information is available at EcoGene: EG10277]. There are three -ketoacyl-ACP synthases (KAS) in Escherichia coli: |FRAME: [More information is available at EcoCyc: EG10277].
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    Genomic context

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    Sequence:
    NC_000913.3 (1148759..1149712)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 50S ribosomal subunit protein L32 Neighboring gene putative phosphate acyltransferase Neighboring gene [acyl-carrier-protein] S-malonyltransferase Neighboring gene 3-oxoacyl-[acyl-carrier-protein] reductase FabG

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of the beta-ketoacyl-acyl carrier protein synthase III gene (fabH) from Escherichia coli K-12. Tsay JT, et al. J Biol Chem, 1992 Apr 5. PMID 1551888
    2. Development of a scintillation proximity assay for beta-ketoacyl-acyl carrier protein synthase III. He X, et al. Anal Biochem, 2000 Jun 15. PMID 10860506
    3. Crystallization of Escherichia coli beta-ketoacyl-ACP synthase III and the use of a dry flash-cooling technique for data collection. Janson CA, et al. Acta Crystallogr D Biol Crystallogr, 2000 Jun. PMID 10818351
    4. 1,2-dithiole-3-ones as potent inhibitors of the bacterial 3-ketoacyl acyl carrier protein synthase III (FabH). He X, et al. Antimicrob Agents Chemother, 2004 Aug. PMID 15273125, Free PMC Article
    5. Expression, purification, and crystallization of the Escherichia coli selenomethionyl beta-ketoacyl-acyl carrier protein synthase III. Khandekar SS, et al. Biochem Biophys Res Commun, 2000 Apr 2. PMID 10733911

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: Isolation and characterization of the beta-ketoacyl-acyl carrier protein synthase III gene (fabH) from Escherichia coli K-12.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables beta-ketoacyl-acyl-carrier-protein synthase III activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-ketoacyl-acyl-carrier-protein synthase III activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in small molecule metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    3-oxoacyl-[acyl carrier protein] synthase 3
    NP_415609.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1148759..1149712
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415609.1 3-oxoacyl-[acyl carrier protein] synthase 3 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415609.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9B052
      Conserved Domains (1) summary
      PRK09352
      Location:1 → 317
      PRK09352; beta-ketoacyl-ACP synthase 3
    Nucleotide Protein
    Heading Accession and Version

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