U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    cysQ 3'(2'),5'-bisphosphate nucleotidase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948728, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    cysQ
    Official Full Name
    3'(2'),5'-bisphosphate nucleotidase
    Primary source
    ECOCYC:EG10043
    Locus tag
    b4214
    See related
    ASAP:ABE-0013786
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    amt; amtA; ECK4210
    Summary
    CysQ is a main target of lithium toxicity in vivo. [More information is available at EcoGene: EG10043]. CysQ is an adenosine-3',5'-bisphosphate nucleotidase which recycles adenosine-3',5'-bisphosphate (PAP) that is generated during sulfate assimilation (see |FRAME: [More information is available at EcoCyc: EG10043].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (4436755..4437495)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transcriptional regulator YtfH Neighboring gene 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase Neighboring gene protein YtfI Neighboring gene PF09695 family protein YtfJ

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. NADP(H) phosphatase activities of archaeal inositol monophosphatase and eubacterial 3'-phosphoadenosine 5'-phosphate phosphatase. Fukuda C, et al. Appl Environ Microbiol, 2007 Sep. PMID 17616624, Free PMC Article
    2. Transposon Tn5supF-based reverse genetic method for mutational analysis of Escherichia coli with DNAs cloned in lambda phage. Phadnis SH, et al. J Bacteriol, 1991 Jan. PMID 1846153, Free PMC Article
    3. Ammonium transport in Escherichia coli: localization and nucleotide sequence of the amtA gene. Fabiny JM, et al. J Gen Microbiol, 1991 Apr. PMID 1856684
    4. Isolation of an ammonium or methylammonium ion transport mutant of Escherichia coli and complementation by the cloned gene. Jayakumar A, et al. J Bacteriol, 1989 Feb. PMID 2536689, Free PMC Article
    5. cysQ, a gene needed for cysteine synthesis in Escherichia coli K-12 only during aerobic growth. Neuwald AF, et al. J Bacteriol, 1992 Jan. PMID 1729235, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 3'(2'),5'-bisphosphate nucleotidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'(2'),5'-bisphosphate nucleotidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3'(2'),5'-bisphosphate nucleotidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfate assimilation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sulfate assimilation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sulfur compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    3'(2'),5'-bisphosphate nucleotidase
    NP_418635.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4436755..4437495
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418635.1 3'(2'),5'-bisphosphate nucleotidase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418635.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1PLB2, A0A485JL03, A0A7A6Y1Y0, A0A7L7EBJ4
      Conserved Domains (1) summary
      PRK10931
      Location:1 → 246
      PRK10931; adenosine-3'(2'),5'-bisphosphate nucleotidase; Provisional
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.