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    galR DNA-binding transcriptional dual regulator GalR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947314, updated on 3-Dec-2024

    Summary

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    Official Symbol
    galR
    Official Full Name
    DNA-binding transcriptional dual regulator GalR
    Primary source
    ECOCYC:EG10364
    Locus tag
    b2837
    See related
    ASAP:ABE-0009307
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2835; Rgal
    Summary
    The "Galactose repressor," GalR, is a DNA-binding transcription factor that represses transcription of the operons involved in transport and catabolism of D-galactose . [More information is available at EcoCyc: EG10364].
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    Genomic context

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    Sequence:
    NC_000913.3 (2976599..2977630)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene diaminopimelate decarboxylase Neighboring gene DNA-binding transcriptional dual regulator LysR Neighboring gene amino acid racemase YgeA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence of galR gene indicates a common evolutionary origin of lac and gal repressor in Escherichia coli. von Wilcken-Bergmann B, et al. Proc Natl Acad Sci U S A, 1982 Apr. PMID 6283521, Free PMC Article
    2. Gal repressosome contains an antiparallel DNA loop. Geanacopoulos M, et al. Nat Struct Biol, 2001 May. PMID 11323719
    3. Recruitment of HU by piggyback: a special role of GalR in repressosome assembly. Kar S, et al. Genes Dev, 2001 Sep 1. PMID 11544184, Free PMC Article
    4. In vitro repression of the gal promoters by GalR and HU depends on the proper helical phasing of the two operators. Lewis DE, et al. J Biol Chem, 2002 Jan 25. PMID 11700313
    5. Genetic analysis of GalR tetramerization in DNA looping during repressosome assembly. Geanacopoulos M, et al. J Biol Chem, 2002 Sep 6. PMID 12065579

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Single amino acid substitutions in GalR affects transcriptional regulation and signal integration logic at engineered promoters.
      Title: Mutations in transcriptional regulators allow selective engineering of signal integration logic.
    2. analysis of galactose repressor mediated intersegmental chromosomal connections in Escherichia coli
      Title: Galactose repressor mediated intersegmental chromosomal connections in Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in galactose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional dual regulator GalR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2976599..2977630
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417314.1 DNA-binding transcriptional dual regulator GalR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417314.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      W1EV50
      Conserved Domains (1) summary
      PRK10727
      Location:1 → 343
      PRK10727; HTH-type transcriptional regulator GalR
    Nucleotide Protein
    Heading Accession and Version

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