U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ubiC chorismate lyase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948545, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ubiC
    Official Full Name
    chorismate lyase
    Primary source
    ECOCYC:EG11369
    Locus tag
    b4039
    See related
    ASAP:ABE-0013227
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4031
    Summary
    Chorismate pyruvate lyase catalyzes the first committed step in the biosynthesis of ubiquinone, the conversion of chorismate to 4-hydroxybenzoate . [More information is available at EcoCyc: EG11369].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (4252506..4253003)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene maltose regulon periplasmic protein Neighboring gene pseudo Neighboring gene 4-hydroxybenzoate octaprenyltransferase Neighboring gene glycerol-3-phosphate 1-O-acyltransferase

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Biosynthesis of ubiquinone in Escherichia coli K-12: biochemical and genetic characterization of a mutant unable to convert chorismate into 4-hydroxybenzoate. Lawrence J, et al. J Bacteriol, 1974 Apr. PMID 4595202, Free PMC Article
    2. Formation of 4-hydroxybenzoate in Escherichia coli: characterization of the ubiC gene and its encoded enzyme chorismate pyruvate-lyase. Siebert M, et al. Microbiology (Reading), 1994 Apr. PMID 8012607
    3. Structural analysis of ligand binding and catalysis in chorismate lyase. Smith N, et al. Arch Biochem Biophys, 2006 Jan 1. PMID 16343413
    4. Aerobic and anaerobic regulation of the ubiCA operon, encoding enzymes for the first two committed steps of ubiquinone biosynthesis in Escherichia coli. Søballe B, et al. FEBS Lett, 1997 Sep 8. PMID 9315722
    5. Crystallization and 1.1-A diffraction of chorismate lyase from Escherichia coli. Stover C, et al. J Struct Biol, 2000 Feb. PMID 10675300

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Cloning and sequencing of Escherichia coli ubiC and purification of chorismate lyase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables chorismate lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chorismate lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chorismate lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chorismate lyase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in pyruvate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquinone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ubiquinone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    chorismate lyase
    NP_418463.4

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4252506..4253003
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418463.4 chorismate lyase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418463.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A775YUH4
      Conserved Domains (1) summary
      PRK11655
      Location:1 → 165
      ubiC; chorismate pyruvate lyase; Provisional
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.