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    thpR RNA 2',3'-cyclic phosphodiesterase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944848, updated on 3-Dec-2024

    Summary

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    Official Symbol
    thpR
    Official Full Name
    RNA 2',3'-cyclic phosphodiesterase
    Primary source
    ECOCYC:EG12330
    Locus tag
    b0147
    See related
    ASAP:ABE-0000505
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0146; ligT; yadP
    Summary
    LigT reversibly ligates RNA to form 2'-5' linkages. [More information is available at EcoCyc: EG12330].
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    Genomic context

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    Sequence:
    NC_000913.3 (161501..162031, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene RNA polymerase-binding transcription factor DksA Neighboring gene sugar fermentation stimulation protein A Neighboring gene RNA-dependent NTPase HrpB Neighboring gene PBP1Bgamma;peptidoglycan glycosyltransferase/peptidoglycan DD-transpeptidase MrcB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure and mechanism of E. coli RNA 2',3'-cyclic phosphodiesterase. Remus BS, et al. RNA, 2014 Nov. PMID 25239919, Free PMC Article
    2. RNA ligase in bacteria: formation of a 2',5' linkage by an E. coli extract. Greer CL, et al. Cell, 1983 Jul. PMID 6347395
    3. Biophysical characterization of cyclic nucleotide phosphodiesterases. Hofmann A, et al. Biochem Biophys Res Commun, 2002 Mar 8. PMID 11866446
    4. DNA and RNA ligases: structural variations and shared mechanisms. Pascal JM. Curr Opin Struct Biol, 2008 Feb. PMID 18262407
    5. Systematic sequencing of the Escherichia coli genome: analysis of the 2.4-4.1 min (110,917-193,643 bp) region. Fujita N, et al. Nucleic Acids Res, 1994 May 11. PMID 8202364, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: The 2'-5' RNA ligase of Escherichia coli. Purification, cloning, and genomic disruption.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA 2',3'-cyclic 3'-phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA 2',3'-cyclic 3'-phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA 2',3'-cyclic 3'-phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA 2',3'-cyclic phosphodiesterase
    NP_414689.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      161501..162031 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414689.4 RNA 2',3'-cyclic phosphodiesterase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414689.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6N8R2Y7
      Conserved Domains (1) summary
      PRK15124
      Location:1 → 176
      PRK15124; RNA 2',3'-cyclic phosphodiesterase
    Nucleotide Protein
    Heading Accession and Version

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