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    hcaE putative 3-phenylpropionate/cinnamate dioxygenase subunit alpha [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946998, updated on 17-Dec-2024

    Summary

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    Official Symbol
    hcaE
    Official Full Name
    putative 3-phenylpropionate/cinnamate dioxygenase subunit alpha
    Primary source
    ECOCYC:M009
    Locus tag
    b2538
    See related
    ASAP:ABE-0008355
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    digA; ECK2535; hcaA; hcaA1; phdC1; yfhU
    Summary
    Hydrocinnamic acid is a synonym for 3-phenylpropionic acid. [More information is available at EcoGene: EG13456].
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    Genomic context

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    Sequence:
    NC_000913.3 (2669032..2670393)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene stationary phase-inducible protein CsiE Neighboring gene putative 3-phenylpropionate transporter Neighboring gene protein IroK Neighboring gene DNA-binding transcriptional dual regulator HcaR Neighboring gene putative 3-phenylpropionate/cinnamate dioxygenase subunit beta Neighboring gene putative 3-phenylpropionate/cinnamate dioxygenase ferredoxin subunit Neighboring gene 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase Neighboring gene putative 3-phenylpropionate/cinnamate dioxygenase ferredoxin reductase subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. 3-phenylpropionate catabolism and the Escherichia coli oxidative stress response. Turlin E, et al. Res Microbiol, 2005 Apr. PMID 15808934
    2. Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli. Burlingame R, et al. J Bacteriol, 1983 Jul. PMID 6345502, Free PMC Article
    3. Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation. Burlingame RP, et al. J Bacteriol, 1986 Oct. PMID 3531186, Free PMC Article
    4. Proteome analysis of Escherichia coli using high-performance liquid chromatography and Fourier transform ion cyclotron resonance mass spectrometry. Ihling C, et al. Proteomics, 2005 May. PMID 15852340
    5. Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12. Díaz E, et al. J Bacteriol, 1998 Jun. PMID 9603882, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3-phenylpropionate dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3-phenylpropionate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within 3-phenylpropionate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in 3-phenylpropionate catabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of 3-phenylpropionate dioxygenase complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative 3-phenylpropionate/cinnamate dioxygenase subunit alpha
    NP_417033.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2669032..2670393
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417033.1 putative 3-phenylpropionate/cinnamate dioxygenase subunit alpha [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417033.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6C9QDD9
      Conserved Domains (2) summary
      cd08881
      Location:184 → 433
      RHO_alpha_C_NDO-like; C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases
      COG4638
      Location:16 → 448
      HcaE; Phenylpropionate dioxygenase or related ring-hydroxylating dioxygenase, large terminal subunit [Inorganic ion transport and metabolism, General function prediction only]
    Nucleotide Protein
    Heading Accession and Version

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