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    trmB tRNA m(7)G46 methyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947448, updated on 17-Dec-2024

    Summary

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    Official Symbol
    trmB
    Official Full Name
    tRNA m(7)G46 methyltransferase
    Primary source
    ECOCYC:EG11779
    Locus tag
    b2960
    See related
    ASAP:ABE-0009714
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2955; trmI; yggH
    Summary
    yggH is renamed trmI in Bjork and Hagervall's EcoSal Module 4.6.2. trmI is a non-essential gene. [More information is available at EcoGene: EG11779]. YggH is a tRNA (m7G46) methyltransferase; it catalyzes N(7)-methylguanosine modification of tRNA at residue G46 . [More information is available at EcoCyc: EG11779].
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    Genomic context

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    Sequence:
    NC_000913.3 (3102133..3102852, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene L-asparaginase 2 Neighboring gene DUF2884 domain-containing protein YggN Neighboring gene putative ribosome assembly factor YggL Neighboring gene adenine DNA glycosylase Neighboring gene putative Fe(2(+))-trafficking protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular mechanism of tRNA binding by the Escherichia coli N7 guanosine methyltransferase TrmB. Schultz SK, et al. J Biol Chem, 2023 May. PMID 36933808, Free PMC Article
    2. Monomeric tRNA (m(7)G46) methyltransferase from Escherichia coli presents a novel structure at the function-essential insertion. Zhou H, et al. Proteins, 2009 Aug 1. PMID 19373903
    3. Crystallization and preliminary crystallographic analysis of tRNA (m(7)G46) methyltransferase from Escherichia coli. Liu Q, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2008 Aug 1. PMID 18678947, Free PMC Article
    4. Sequence-structure-function relationships of a tRNA (m7G46) methyltransferase studied by homology modeling and site-directed mutagenesis. Purta E, et al. Proteins, 2005 May 15. PMID 15789416
    5. 7-Methylguanine specific tRNA-methyltransferase from Escherichia coli. Aschhoff HJ, et al. Nucleic Acids Res, 1976 Nov. PMID 794833, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular mechanism of tRNA binding by the Escherichia coli N7 guanosine methyltransferase TrmB.
      Title: Molecular mechanism of tRNA binding by the Escherichia coli N7 guanosine methyltransferase TrmB.
    2. Monomeric tRNA (m(7)G46) methyltransferase from Escherichia coli presents a novel structure at the function-essential insertion
      Title: Monomeric tRNA (m(7)G46) methyltransferase from Escherichia coli presents a novel structure at the function-essential insertion.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (guanine(46)-N7)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA (guanine(46)-N7)-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA (guanine(46)-N7)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA (guanine-N7)-methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tRNA (guanine-N7)-methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within tRNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of tRNA methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tRNA m(7)G46 methyltransferase
    NP_417435.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3102133..3102852 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417435.1 tRNA m(7)G46 methyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417435.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S0FLI8
      Conserved Domains (1) summary
      COG0220
      Location:17 → 239
      TrmB; tRNA G46 methylase TrmB [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version

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